Molecular Human Reproduction, Vol. 6, No. 1, 55-59,
January 2000
© 2000 European Society of Human Reproduction and Embryology
Uterus and pregnancy |
Tissue differences but limited sex steroid responsiveness of c-fos and c-jun in human fibroids and myometrium
1 Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge and 2 Department of Women's and Children's Health, Section of Obstetrics and Gynecology, Uppsala University Hospital, Uppsala, Sweden
Abstract
Sex steroids influence the growth of mammalian uterine tissues and the proto-oncogenes c-fos and c-jun have been implicated in the cascade of cellular events induced by the cyclic influence of oestrogen and progesterone. To investigate the role of these proto-oncogenes for fibroid growth their mRNA expression was measured in myometrium and fibroids under different hormonal conditions, using a solution hybridization method. Fibroids and myometrium were collected at surgery from premenopausal, postmenopausal and pregnant women as well as women treated with a gonadotrophin releasing hormone agonist (GnRHa; Goserelin). The phase of the menstrual cycle was determined in all the untreated, premenopausal, non-pregnant women. The mRNA expression of c-fos and c-jun in fibroids was significantly lower than in homologous myometrium. No significant differences in c-fos expression were observed in myometrium, or fibroids, due to menstrual cycle phase, GnRHa treatment, pregnancy or the menopause. The c-jun expression in myometrium from pregnant women without fibroid disease was significantly higher than the corresponding control myometrium from premenopausal, non-pregnant women. These results demonstrate a tissue difference in the expression of c-fos and c-jun between myometrium and fibroids.
fibroids/hormones/human/proto-oncogenes
Notes
3 To whom correspondence should be addressed
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