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Molecular Human Reproduction, Vol. 6, No. 10, 929-933, October 2000
© 2000 European Society of Human Reproduction and Embryology

Uterine physiology

Increased concentrations of soluble tumour necrosis factor receptor (sTNFR) I and II in peritoneal fluid from women with endometriosis

Kaori Koga1, Yutaka Osuga1, Osamu Tsutsumi1,2, Ryugo Okagaki1, Mikio Momoeda1, Tetsu Yano1, Toshihiro Fujiwara1, Yasushi Takai1, Koji Kugu1, Yutaka Morita1 and Yuji Taketani1,3

1 Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, and 2 CREST, Japan Science and Technology, Kawaguchi 332-0012, Japan

Abstract

Tumour necrosis factor {alpha} (TNF{alpha}), a proapoptotic cytokine, is known to be present in peritoneal fluid from women with endometriosis. An emerging view is that soluble TNF receptors (sTNFR) can modulate the effects of TNF{alpha} by acting as TNF{alpha} antagonists. To assess the relevance of sTNFRs in the pathophysiology of endometriosis, concentrations of sTNFR I, sTNFR II and TNF{alpha} in peritoneal fluid from women with endometriosis (n = 53) and without endometriosis (n = 40) were measured. Concentrations of both sTNFR I and sTNFR II in peritoneal fluid from women with endometriosis were significantly higher than in peritoneal fluid from women without endometriosis, both in the follicular and the luteal phases. TNF{alpha} concentrations did not differ in patients with and without endometriosis in both phases. When stratified by the stage of the disease, women with both stages I/II and stages III/IV exhibited significantly higher concentrations of sTNFR I and sTNFR II in peritoneal fluid, compared with women without endometriosis, whereas no appreciable difference in the concentrations was detected between stages I/II and stages III/IV. A significant correlation was found between the concentrations of sTNFR I and sTNFR II; while the correlations between TNF{alpha} and sTNFR I or sTNFR II, were either not significant or were very weak. Furthermore, mRNA for the membrane-associated TNF receptor type 1 and TNF receptor type 2, both of which convey the effects of TNF{alpha}, were shown to be expressed in endometriotic tissues as well as eutopic endometrium. Together, these findings suggest a possible involvement of sTNFRs in the pathophysiology of endometriosis.

endometriosis/infertility/peritoneal fluid/soluble TNF receptor/TNF{alpha}

Notes

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan. E-mail: taketani-tky{at}umin.ac.jp


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