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Molecular Human Reproduction, Vol. 6, No. 10, 935-941, October 2000
© 2000 European Society of Human Reproduction and Embryology

Pregnancy

Expression of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in conceptus and endometrium during implantation in the rhesus monkey

D. Ghosh1, A.M. Sharkey2, D.S. Charnock-Jones2, Latika Dhawan1, S. Dhara1, S.K. Smith2 and Jayasree Sengupta1,3

1 Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India, and 2 Department of Obstetrics and Gynaecology, Rosie Maternity Hospital, University of Cambridge, Cambridge, UK

Abstract

The aim of this study was to analyse the expression of transcripts and proteins for vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) in different compartments of the early conceptus at primary implantation sites during lacunar (n = 6), early villous (n = 9) and villous placenta (n = 6) stages of gestation in the rhesus monkey. During the lacunar stage, VEGF expression was observed in the cytotrophoblast cells lining the extraembryonic cavity, but these cells did not express PlGF. With further development, cytotrophoblast cells lining villi, forming columns, and constituting anchoring villi, expressed both VEGF and PlGF during early villous and villous placenta stages. In addition, chorion, amnion and villous stromal cells expressed both VEGF and PlGF proteins and mRNA. During the lacunar stage, all epithelial cells in maternal endometrium generally expressed VEGF, while PlGF expression was observed in the plaque epithelium only. As gestation advanced, the expression of VEGF and PlGF from plaque cells decreased, and in surface and glandular epithelium the expression of VEGF increased, while the expression of PlGF remained unaltered. Decidual stromal cells expressed VEGF and PlGF only at low levels during the lacunar stage, while the expression of both increased during the early villous and the villous placenta stages of implantation. It appears from the present study that the expression of VEGF and PlGF are regulated in a temporal and spatial manner during early stages of implantation and that their concerted actions in placental and maternal compartments play a critical role in the evolving pregnancy in the rhesus monkey.

cytotrophoblast/implantation/placental growth factor/rhesus monkey/vascular endothelial growth factor

Notes

3 To whom correspondence should be addressed at: Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029, India. E-mail: jayasreesengupta{at}hotmail.com


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