Molecular Human Reproduction, Vol. 6, No. 10, 959-965,
October 2000
© 2000 European Society of Human Reproduction and Embryology
Pregnancy |
Local fetal signal is not required for maintaining IGFBP gene expression in the human decidua: evidence from extrauterine pregnancies
1 MRC Group in Fetal and Neonatal Health and Development, The Lawson Research Institute, The Child Health Research Institute, and Departments of Pediatrics, Obstetrics and Gynaecology, and Biochemistry, University of Western Ontario, London, Canada, 2 Department of Pathology, University of Western Ontario, London, Canada and 3 Department of Obstetrics and Gynaecology, University of Giessen, Giessen, Germany
Abstract
Insulin-like growth factor-II (IGF-II) from the invading extravillous cytotrophoblasts (EVTs) and insulin-like growth factor binding proteins (IGFBPs) from the maternal decidua interact at the feto–maternal interface and regulate implantation and placentation. To determine whether a local stimulus from the fetus is important in the regulation of IGFBP gene expression in the human decidua, we compared the expression of IGFBP genes in intra- and extrauterine (tubal) pregnancies. The expression of IGF-II and IGFBP-1 to IGFBP-6 mRNAs was determined by in-situ hybridization in the Fallopian tubes of extrauterine pregnancies and concurrent decidua (n = 6), and in the placentae and Fallopian tubes of intrauterine pregnancies (n = 6). All six IGFBP mRNAs were identified in the decidualized endometrium and decidualized Fallopian tubes of intra- and extrauterine pregnancies, with IGFBP-1 mRNA being the predominant mRNA. IGFBP-4 was the second most predominant mRNA and was slightly more abundant in the decidua of extrauterine pregnancies than of intrauterine pregnancies. IGF-II mRNA was expressed mainly in cells of fetal origin. The fact that the IGFBP mRNAs were expressed similarly in both intra- and extrauterine pregnancies indicates that the local physical stimulus from an implanting fetus is not necessary to induce or maintain decidual IGFBP gene expression.
decidual cells/endometrium/extrauterine pregnancy/IGF-II
Notes
4 To whom correspondence should be addressed at: H308, The Lawson Research Institute, 268 Grosvenor Street, London, Ontario, Canada. E-mail: vhan{at}julian.uwo.ca
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