Molecular Human Reproduction, Vol. 6, No. 12, 1107-1117,
December 2000
© 2000 European Society of Human Reproduction and Embryology
Uterine physiology |
Inhibin and activin subunits are differentially expressed in endometrial cells and leukocytes during the menstrual cycle, in early pregnancy and in women using progestin-only contraception
1 Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Victoria 3168, Australia, 2 Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, EH3 9EW, UK, 3 Monash University Dept. of Obstetrics and Gynaecology, Clayton, Victoria 3168, Australia, and 4 Human Reproduction Study Group, Department of Obstetrics and Gynaecology, University of Indonesia, Klinik Raden Salah, Jalan Raden Salah 49, Jakarta, 10330, Indonesia
Abstract
Inhibins and activins are dimeric hormones which share common subunits and which have diverse endocrine and paracrine roles in regulating reproductive function. Endometrial expression of inhibin 
, ßA and ßB subunits was examined by immunohistochemistry and in-situ hybridization, across the menstrual cycle and in early pregnancy. All three subunits were found to be expressed in endometrium, primarily by glandular epithelium in the early stages of the cycle. Following the onset of decidualization, expression of , ßA and ßB subunits was up-regulated in decidualized stromal cells. A marked down-regulation of subunit was detected in glandular epithelium, whilst expression of ßA and ßB subunits was maintained. This pattern was consistent in decidua from early pregnancy and additionally in endometrium from women using progestin-only contraceptives, either subdermal implants (Norplant®) or levonorgestrel-releasing intrauterine systems (Lng-IUS). Immunostaining was also observed for both ßA and ßB subunits in subpopulations of endometrial leukocytes, identified to be distinct subsets of macrophages, neutrophils and mast cells. Potential paracrine roles for activins may be envisaged in facilitating tissue remodelling during decidualization, in tissue repair following menstruation, and additionally in modulating premenstrual inflammatory events.
activin/decidualization/endometrium/inhibin/leukocyte
Notes
5 To whom correspondence should be addressed at: Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Victoria 3168, Australia. E-mail: Rebecca.Jones{at}med.monash.edu.au
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