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Molecular Human Reproduction, Vol. 6, No. 4, 369-374, April 2000
© 2000 European Society of Human Reproduction and Embryology

Pregnancy

Modulation of indoleamine 2,3-dioxygenase by interferon-{gamma} in human placental chorionic villi

Yoshiki Kudo1,3, C.A.R. Boyd1, I.L. Sargent2 and C.W.G. Redman2

1 Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX and 2 Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK

Abstract

The effect of interferon-{gamma} on indoleamine 2,3-dioxygenase, a tryptophan catabolizing enzyme, was studied in cultured human placental chorionic villi. The activity of indoleamine 2,3-dioxygenase was markedly stimulated by interferon-{gamma} in a time- and concentration-dependent manner. Interferon-{alpha} and interferon-ß also showed a slight stimulatory effect on indoleamine 2,3-dioxygenase activity. The level of indoleamine 2,3-dioxygenase mRNA expression (determined by reverse transcription—polymerase chain reaction) was also enhanced by interferon-{gamma}. Interleukin-4 showed a dose-dependent inhibitory effect on interferon-{gamma}-induced stimulation of indoleamine 2,3-dioxygenase activity and mRNA expression.

human placenta/indoleamine 2,3-dioxygenase/interferon/interleukin

Notes

3 To whom correspondence should be addressed


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