Molecular Human Reproduction, Vol. 6, No. 4, 369-374,
April 2000
© 2000 European Society of Human Reproduction and Embryology
Pregnancy |
Modulation of indoleamine 2,3-dioxygenase by interferon-
in human placental chorionic villi
1 Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX and 2 Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Abstract
The effect of interferon-
on indoleamine 2,3-dioxygenase, a tryptophan catabolizing enzyme, was studied in cultured human placental chorionic villi. The activity of indoleamine 2,3-dioxygenase was markedly stimulated by interferon- in a time- and concentration-dependent manner. Interferon-
and interferon-ß also showed a slight stimulatory effect on indoleamine 2,3-dioxygenase activity. The level of indoleamine 2,3-dioxygenase mRNA expression (determined by reverse transcription—polymerase chain reaction) was also enhanced by interferon-. Interleukin-4 showed a dose-dependent inhibitory effect on interferon--induced stimulation of indoleamine 2,3-dioxygenase activity and mRNA expression.
human placenta/indoleamine 2,3-dioxygenase/interferon/interleukin
Notes
3 To whom correspondence should be addressed
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. M. Gasparri, E. Jachetti, B. Colombo, A. Sacchi, F. Curnis, G.-P. Rizzardi, C. Traversari, M. Bellone, and A. Corti Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFN{gamma} Mol. Cancer Ther., December 1, 2008; 7(12): 3859 - 3866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kudo, T. Hara, T. Katsuki, A. Toyofuku, Y. Katsura, O. Takikawa, T. Fujii, and K. Ohama Mechanisms regulating the expression of indoleamine 2,3-dioxygenase during decidualization of human endometrium Hum. Reprod., May 1, 2004; 19(5): 1222 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Mackler, E. M. Barber, O. Takikawa, and J. W. Pollard Indoleamine 2,3-Dioxygenase Is Regulated by IFN-{gamma} in the Mouse Placenta During Listeria monocytogenes Infection J. Immunol., January 15, 2003; 170(2): 823 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sedlmayr, A. Blaschitz, R. Wintersteiger, M. Semlitsch, A. Hammer, C.R. MacKenzie, W. Walcher, O. Reich, O. Takikawa, and G. Dohr Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta Mol. Hum. Reprod., April 1, 2002; 8(4): 385 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kudo, C A R Boyd, I L Sargent, and C W G Redman Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation J. Physiol., August 15, 2001; 535(1): 207 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kudo and C A R Boyd The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants J. Physiol., March 1, 2001; 531(2): 417 - 423. [Abstract] [Full Text] [PDF]
|
|