Molecular Human Reproduction, Vol. 6, No. 6, 561-565,
June 2000
© 2000 European Society of Human Reproduction and Embryology
Pregnancy |
NF-
B and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH)
1 Imperial College School of Medicine, Institute of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 OXG, and 2 National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
Abstract
Prostaglandins are known to play an important role in human labour and are used clinically to induce labour onset. Cytokines, e.g. interleukin 1 ß (IL-1ß), are up-regulated in the amniotic fluid late in gestation and can increase prostaglandin production through the expression of cyclo-oxygenase 2 (COX-2), the prostaglandin synthetic isoform involved in human labour. We demonstrate in immortalized amnion epithelial (WISH) cells, that IL-1ß causes increased transcription of the COX-2 gene. Luciferase reporter constructs with site-directed mutagenesis of the two NF-
B sites and an AP-1 site in the COX-2 promoter showed reduced expression of luciferase in transient transfection studies. This suggests that the binding of transcription factors to these sites is essential for the regulation of COX-2 transcription in IL-1ß-treated WISH cells.
cyclo-oxygenase 2/gene expression/parturition/transcription factors
Notes
3 To whom correspondence should be addressed at: Imperial College School of Medicine, Institute of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London, W6 OXG, UK. E-mail v.allport{at}ic.ac.uk
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