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Molecular Human Reproduction, Vol. 6, No. 7, 587-590, July 2000
© 2000 European Society of Human Reproduction and Embryology

Ovary and oogenesis

Preliminary investigation of follistatin gene mutations in women with polycystic ovary syndrome

W.X. Liao, A.C. Roy1 and S.C. Ng

Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Lower Kent Ridge Road, Singapore 119074

Abstract

Strong evidence for a link between the follistatin gene and polycystic ovary syndrome (PCOS) has recently been found in a well-designed large-scale study. Follistatin binds to activin and affects its functions, e.g. stimulation of FSH synthesis and secretion. Thus, it may play a role in the functional impairment of the FSH–granulosa cell axis in PCOS. In this study, we screened 64 Chinese patients with PCOS for mutations in the entire coding region (including the region encoding alternative carboxy-terminals) of the follistatin gene using polymerase chain reaction (PCR)-based single-stranded conformational polymorphism (SSCP) and DNA sequencing. However, we could not identify a single mutation of either the activating or inhibiting type, using these techniques. Therefore, it would appear that PCOS in the local Chinese population is not caused by mutations in the coding regions of the follistatin gene.

follistatin gene/mutation/polycystic ovary syndrome/single-stranded conformational polymorphism

Notes

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Lower Kent Ridge Road, Singapore 119074. E-mail: obgroyac{at}nus.edu.sg


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