Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Liao, W.X.
Right arrow Articles by Ng, S.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liao, W.X.
Right arrow Articles by Ng, S.C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Human Reproduction, Vol. 6, No. 7, 587-590, July 2000
© 2000 European Society of Human Reproduction and Embryology

Ovary and oogenesis

Preliminary investigation of follistatin gene mutations in women with polycystic ovary syndrome

W.X. Liao, A.C. Roy1 and S.C. Ng

Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Lower Kent Ridge Road, Singapore 119074

Abstract

Strong evidence for a link between the follistatin gene and polycystic ovary syndrome (PCOS) has recently been found in a well-designed large-scale study. Follistatin binds to activin and affects its functions, e.g. stimulation of FSH synthesis and secretion. Thus, it may play a role in the functional impairment of the FSH–granulosa cell axis in PCOS. In this study, we screened 64 Chinese patients with PCOS for mutations in the entire coding region (including the region encoding alternative carboxy-terminals) of the follistatin gene using polymerase chain reaction (PCR)-based single-stranded conformational polymorphism (SSCP) and DNA sequencing. However, we could not identify a single mutation of either the activating or inhibiting type, using these techniques. Therefore, it would appear that PCOS in the local Chinese population is not caused by mutations in the coding regions of the follistatin gene.

follistatin gene/mutation/polycystic ovary syndrome/single-stranded conformational polymorphism

Notes

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Lower Kent Ridge Road, Singapore 119074. E-mail: obgroyac{at}nus.edu.sg


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Hum ReprodHome page
M.R. Jones, S.G. Wilson, B.H. Mullin, R. Mead, G.F. Watts, and B.G.A. Stuckey
Polymorphism of the follistatin gene in polycystic ovary syndrome
Mol. Hum. Reprod., April 1, 2007; 13(4): 237 - 241.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Qin, D. A. Ehrmann, N. Cox, S. Refetoff, and R. L. Rosenfield
Identification of a Functional Polymorphism of the Human Type 5 17{beta}-Hydroxysteroid Dehydrogenase Gene Associated with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 270 - 276.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
H. F. Escobar-Morreale, M. Luque-Ramirez, and J. L. San Millan
The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome
Endocr. Rev., April 1, 2005; 26(2): 251 - 282.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. J. Jorgez, M. Klysik, S. P. Jamin, R. R. Behringer, and M. M. Matzuk
Granulosa Cell-Specific Inactivation of Follistatin Causes Female Fertility Defects
Mol. Endocrinol., April 1, 2004; 18(4): 953 - 967.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Eldar-Geva, I.M. Spitz, N.P. Groome, E.J. Margalioth, and R. Homburg
Follistatin and activin A serum concentrations in obese and non-obese patients with polycystic ovary syndrome
Hum. Reprod., December 1, 2001; 16(12): 2552 - 2556.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. J. Norman, C. R. Milner, N. P. Groome, and D. M. Robertson
Circulating follistatin concentrations are higher and activin concentrations are lower in polycystic ovarian syndrome
Hum. Reprod., April 1, 2001; 16(4): 668 - 672.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.