Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (17)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Blagosklonova, O.
Right arrow Articles by Bresson, J.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blagosklonova, O.
Right arrow Articles by Bresson, J.-L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Human Reproduction, Vol. 6, No. 9, 795-799, September 2000
© 2000 European Society of Human Reproduction and Embryology

Testis and spermatogenesis

AZFa deletions in Sertoli cell-only syndrome: a retrospective study

O. Blagosklonova1, F. Fellmann, M.-C. Clavequin, C. Roux and J.-L. Bresson

Service de Cytogénétique-Immunocytologie-Biologie du Développement et de la Reproduction, CHU et CNRS UPRESA 6025, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030 Besancion cedex, France

Abstract

Lack of data on the genotype–phenotype relationship in cases of AZF microdeletions is due to the limited number of histological investigations in human male infertility cases. We investigated the possibility of retrospective detection of Yq11 microdeletions by using DNA extracted from diagnostic testicular biopsies. We used histological criteria to select two series of material: 22 biopsies with Sertoli cell-only syndrome and 14 biopsies with maturation arrest at the spermatocyte I stage. Two markers, DFFRY and DAZ, were tested by nested polymerase chain reaction (PCR) in the two series. In the Sertoli cell-only syndrome series, we found four deletions affecting the DFFRY gene (18.2%). In the second series, no deletions were detected. Two conclusions may be considered, although the number of specimens analysed is limited: (i) the frequency of deletions observed in Sertoli cell-only syndrome allows us to suggest that deletion in the AZFa region may be involved in this pathology; and (ii) retrospective studies may yield some additional elements in our search for eventual genotype–phenotype relationships.

AZF/DFFRY/male infertility/Sertoli cell-only syndrome/Y chromosome

Notes

1 To whom correspondence should be addressed at: Service de Cytogénétique-Immunocytologie-Biologie du Développement et de la Reproduction, CHU et CNRS UPRESA 6025, Faculté de Médecine et de Pharmacie. Place Saint-Jacques, 25030 Besancion cedex, France. E-mail: oxana_blagoskl{at}hotmail.com


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
A. Ferlin, B. Arredi, E. Speltra, C. Cazzadore, R. Selice, A. Garolla, A. Lenzi, and C. Foresta
Molecular and Clinical Characterization of Y Chromosome Microdeletions in Infertile Men: A 10-Year Experience in Italy
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 762 - 770.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
G. H. Perry, R. Y. Tito, and B. C. Verrelli
The Evolutionary History of Human and Chimpanzee Y-Chromosome Gene Loss
Mol. Biol. Evol., March 1, 2007; 24(3): 853 - 859.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
P. H. Vogt
AZF deletions and Y chromosomal haplogroups: history and update based on sequence
Hum. Reprod. Update, July 1, 2005; 11(4): 319 - 336.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.M. Luetjens, J. Gromoll, M. Engelhardt, S. von Eckardstein, M. Bergmann, E. Nieschlag, and M. Simoni
Manifestation of Y-chromosomal deletions in the human testis: a morphometrical and immunohistochemical evaluation
Hum. Reprod., September 1, 2002; 17(9): 2258 - 2266.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
O. Blagosklonova, C. Joanne, C. Roux, H. Bittard, F. Fellmann, and J.L. Bresson
Absence of anti-Mullerian hormone (AMH) and M2A immunoreactivities in Sertoli cell-only syndrome and maturation arrest with and without AZF microdeletions
Hum. Reprod., August 1, 2002; 17(8): 2062 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
C. Kamp, K. Huellen, S. Fernandes, M. Sousa, P.N. Schlegel, A. Mielnik, S. Kleiman, H. Yavetz, W. Krause, W. Kupker, et al.
High deletion frequency of the complete AZFa sequence in men with Sertoli-cell-only syndrome
Mol. Hum. Reprod., October 1, 2001; 7(10): 987 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
L. Van Landuyt, W. Lissens, K. Stouffs, H. Tournaye, A. Van Steirteghem, I. Liebaers, O. Blagosklonova, and J-L. Bresson
The role of USP9Y and DBY in infertile patients with severely impaired spermatogenesis
Mol. Hum. Reprod., July 1, 2001; 7(7): 691 - 693.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.