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Molecular Human Reproduction, Vol. 7, No. 1, 43-47, January 2001
© 2001 European Society of Human Reproduction and Embryology

Ovary and oogenesis

Dual effects of nitric oxide in functional and regressing rat corpus luteum

A.B. Motta1, A. Estevez, T. Tognetti, M.A.F. Gimeno and A.M. Franchi

Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Serrano 669, 1414 Buenos Aires, Argentina

Abstract

The present study investigated the effect of nitric oxide (NO) on the lifespan of the corpus luteum (CL). Using a competitive nitric oxide synthase (NOS) inhibitor, L-nitro arginine methyl ester (L-NAME, 600 µmol/l), and a long-life NO donor, diethyl-aminetriamine (DETA-NONOate, 10–8, 10– 6 or 10– 4 mol/l), we found that in ovaries from rats at the mid stage of CL development, endogenous NO increased both glutathione (GSH) and progesterone production. However, during prostaglandin F2{alpha} (PGF2{alpha})-induced luteolysis NO acted as an intermediary molecule in the inhibitory effect of PGF2{alpha}, on GSH content. This was supported by the fact that in-vivo PGF2{alpha} treatment enhanced nitric oxide synthase (NOS) activity. These results indicate that the NO could act with a dual action (protective or pro-oxidant) in CL development.

corpus luteum/glutathione/luteolysis/nitric oxide/prostaglandin

Notes

1 To whom correspondence should be addressed. E-mail: amotta{at}sion.com


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