Molecular Human Reproduction, Vol. 7, No. 12, 1167-1172,
December 2001
© 2001 European Society of Human Reproduction and Embryology
Implantation and pregnancy |
HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage
1 Departments of Human Genetics and 3 Health Studies, The University of Chicago, 2 Department of Obstetrics and Gynecology, University of British Columbia, 4 Department of Obstetrics and Gynecology, Washington University School of Medicine and 5 Department of Obstetrics and Gynecology, University of Utah School of Medicine, USA
HLA-G is a non-classical human leukocyte antigen expressed primarily in fetal tissues at the maternal–fetal interface. This expression pattern is unique among HLA genes and suggests that HLA-G may be involved in interactions that are critical in establishing and/or maintaining pregnancy. To evaluate the role of polymorphisms at this locus in maternal–fetal interactions, 113 couples with unexplained recurrent miscarriage were genotyped for seven polymorphisms that define 12 HLA-G alleles. Logistic regression analysis was used to assess whether HLA-G genotypes were associated with an increased risk for a subsequent miscarriage. The presence of an HLA-G*0104 or HLA-G*0105N allele in either partner was significantly associated with an increased risk for miscarriage, after adjustment for maternal age, number of previous miscarriages, history of a previous liveborn, and treatment with paternal mononuclear cells. The *0104 and *0105N alleles are defined by polymorphisms in the 
-2 domain and encode protein variants that are present only in the full-length HLA-G1 protein. The significant genotype-specific risk in this population suggests that allelic variation in the -2 domain of the HLA-G1 isoforms contributes to recurrent miscarriage.
human leukocyte antigen/recurrent miscarriage/HLA-G
6 To whom correspondence should be addressed at: Department of Human Genetics, The University of Chicago, 920 E. 58th Street, Rm. 507C, Chicago, IL 60637, USA. E-mail: c-ober{at}genetics.uchicago.edu
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Moreau, L. Contu, F. Alba, S. Lai, R. Simoes, S. Orru, C. Carcassi, M. Roger, M. Rabreau, and E. D. Carosella HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage Biol Reprod, September 1, 2008; 79(3): 459 - 467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. V. F. Hviid HLA-G in human reproduction: aspects of genetics, function and pregnancy complications Hum. Reprod. Update, May 1, 2006; 12(3): 209 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Tan, A. M. Shon, and C. Ober Evidence of balancing selection at the HLA-G promoter region Hum. Mol. Genet., December 1, 2005; 14(23): 3619 - 3628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Le Discorde, C. Le Danff, P. Moreau, N. Rouas-Freiss, and E. D. Carosella HLA-G*0105N Null Allele Encodes Functional HLA-G Isoforms Biol Reprod, August 1, 2005; 73(2): 280 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Sata, H. Yamada, K. Suzuki, Y. Saijo, E. H Kato, M. Morikawa, H. Minakami, and R. Kishi Caffeine intake, CYP1A2 polymorphism and the risk of recurrent pregnancy loss Mol. Hum. Reprod., May 1, 2005; 11(5): 357 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.S. Witt, J. Goodridge, M.G. Gerbase-DeLima, S. Daher, and F.T. Christiansen Maternal KIR repertoire is not associated with recurrent spontaneous abortion Hum. Reprod., November 1, 2004; 19(11): 2653 - 2657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Saijo, F. Sata, H. Yamada, K. Suzuki, S. Sasaki, T. Kondo, Y.Y. Gong, E.H. Kato, S. Shimada, M. Morikawa, et al. Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss Mol. Hum. Reprod., October 1, 2004; 10(10): 729 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sata, H. Yamada, A. Yamada, E. H. Kato, S. Kataoka, Y. Saijo, T. Kondo, J. Tamaki, H. Minakami, and R. Kishi A polymorphism in the CYP17 gene relates to the risk of recurrent pregnancy loss Mol. Hum. Reprod., November 1, 2003; 9(11): 725 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.S. Hunt, J.L. Pace, P.J. Morales, and C. Ober Immunogenicity of the soluble isoforms of HLA-G Mol. Hum. Reprod., November 1, 2003; 9(11): 729 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Patel, K. C. Quack, J. A. Hill, and D. J. Schust Expression of membrane-bound HLA-G at the maternal-fetal interface is not associated with pregnancy maintenance among patients with idiopathic recurrent pregnancy loss Mol. Hum. Reprod., September 1, 2003; 9(9): 551 - 557. [Abstract] [Full Text] [PDF]
|
|