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Molecular Human Reproduction, Vol. 7, No. 4, 325-331, April 2001
© 2001 European Society of Human Reproduction and Embryology

The balance between MMP-9 and MMP-2 and their tissue inhibitor (TIMP)-1 in luteinized granulosa cells: comparison between women with PCOS and normal ovulatory women

Eliezer Shalev1,2,3, Shlomit Goldman1 and Izhar Ben-Shlomo1,2

1 Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha'Emek Medical Center, Afula and 2 Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel

Polycystic ovarian syndrome (PCOS) involves follicular atresia, formation of multiple ovarian cysts and is frequently associated with a higher abortion rate. Follicular development, ovulation, formation of corpus luteum and its regression involve extensive tissue remodelling. Mammalian ovaries express a number of matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP). We assessed the differences in production of MMP-2, MMP-9 and TIMP-1 by cultured luteinized granulosa cells from women with PCOS and normal ovulatory women after ovarian stimulation for IVF treatment. In follicular fluid from women with PCOS, levels of MMP-9 and MMP-2 were higher than the normal group, as was the basal production of these proteins by cultured cells. Basal production of TIMP-1 by cultured cells was not different between PCOS and normal groups. A time-dependent increase in the production of MMP-9 was observed in cells from both normal and PCOS women, although the increase was more pronounced in the latter. Thus the MMP-TIMP balance is shifted toward greater MMP activity in luteinized granulosa cells from women with PCOS.

luteinized granulosa cells/MMP/polycystic ovarian syndrome/TIMP

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Ha'Emek Medical Centre, Afula 18101, Israel. E-mail: shalev_e{at}clalit.org.il


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