Molecular Human Reproduction, Vol. 8, No. 2, 176-180,
February 2002
© 2002 European Society of Human Reproduction and Embryology
Uterine physiology |
Expression of interferon-
-inducible protein-10 in human endometrial stromal cells
Department of Obstetrics and Gynecology, Oita Medical University, Hasama-machi, Oita 879-5593, Japan
Human endometrial stromal cells (ESC) can produce a variety of chemokines, especially after inflammatory stimulation. Interferon-
-inducible protein-10 (IP-10) is a potent chemoattractant for lymphocytes, and belongs to the family of non-ELR CXC chemokines. The expression of IP-10 in ESC after stimulation with interferon- (IFN-), interleukin-1ß (IL-1ß), tumour necrosis factor-
(TNF-), or lipopolysaccharide (LPS) was evaluated using an enzyme-linked immunosorbent assay and Northern blot analysis. A small amount of IP-10 protein was detected in the culture media of unstimulated ESC. The expression of IP-10 mRNA was detected in ESC. IFN-, IL-1ß, TNF- and LPS significantly stimulated the expression of IP-10 mRNA and protein in ESC. These results suggest that the production of IP-10 by ESC is regulated by inflammatory mediators. The modulation of IP-10 concentrations in the local environment may contribute to the normal and pathological processes of human reproduction by regulating leukocyte trafficking in the endometrium.
endometrial stromal cell/interferon--inducible protein-10/interferon-/interleukin-1ß/tumor necrosis factor-
1 To whom correspondence should be addressed. E-mail: nasu{at}oita-med.ac.jp
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