Molecular Human Reproduction, Vol. 8, No. 2, 181-187,
February 2002
© 2002 European Society of Human Reproduction and Embryology
Implantation and pregnancy |
Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D2-mediated manner
1 Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-0194, 2 R&D Center, BML, Kawagoe, Saitama 350-1101 and 3 Human Gene Sciences Center, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
T-helper (Th) 2-type cytokines predominate in decidua, plausibly accounting for protection of a semiallograft, the embryo and placenta, from attack by the maternal immune system. However, localization of Th2 and T-cytotoxic (Tc) 2 cells in decidua has not been reported, presumably because of the difficulty in detecting intracellular cytokines in tissues. Here, by staining tissues for a novel surface maker of Th2/Tc2, the chemoattractant receptor-homologous molecule CRTH2, which is expressed on Th2 cells, we show that CRTH2+ Th2 cells and CRTH2+ Tc2 cells are significantly increased at the materno–fetal interface (implantation site) in decidua. We also show that trophoblast, uterine epithelium and endometrial glands all express haematopoietic-type prostaglandin (PG) D2 synthase (hPGDS). Since CRTH2 is a chemoattractant receptor for PGD2 and mediates PGD2-dependent migration of blood Th2 cells, our findings suggest that Th2 and Tc2 cells may be recruited to the materno–fetal interface, at least in part in a PGD2-mediated manner.
CRTH2/decidua/PGD2/pregnancy/Th2
4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani Toyama-shi, Toyama 930-0194, Japan. E-mail: s30saito{at}ms.toyama-mpu.ac.jp
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