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Molecular Human Reproduction, Vol. 8, No. 3, 281-285, March 2002
© 2002 European Society of Human Reproduction and Embryology

Implantation and pregnancy

The effects of a cytokine suppressive anti-inflammatory drug on the output of prostaglandin E2 and interleukin-1ß from human fetal membranes

M.H.F. Sullivan,1, S.A. Alvi, N.L. Brown, M.G. Elder and P.R. Bennett

Institute of Reproductive and Developmental Biology, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

Fetal membranes are a primary source of prostaglandins and pro-inflammatory cytokines implicated in human parturition, so the inhibition of inflammatory pathways may be of benefit in pregnancies complicated by premature labour. We have therefore investigated the effects of a cytokine-suppressant anti-inflammatory drug (CSAID) on the output of prostaglandin E2 (PGE2) and interleukin (IL)-1ß from human fetal membranes in vitro. Bacterial endotoxin increased the expression of mRNA for IL-1ß and type-2 cyclo-oxygenase (COX-2), and there were corresponding increases in the output of IL-1ß protein and PGE2. The CSAID decreased IL-1ß protein, COX-2 expression and PGE2 output, but not mRNA for IL-1ß, indicating a post-translational effect on the production of IL-1ß and a transcriptional affect on COX-2, with an overall reduction in PGE2. These findings are consistent with the effects of CSAIDs in other systems, and indicate that they are of possible use in premature labour.

CSAID/fetal membranes/interleukin-1ß/labour/prostaglandin E2

1 To whom correspondence should be addressed. E-mail: mark.sullivan{at}ic.ac.uk


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