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Molecular Human Reproduction, Vol. 8, No. 5, 426-433, May 2002
© 2002 European Society of Human Reproduction and Embryology

Ovary and oogenesis

FSH-regulated gene expression profiles in ovarian tumours and normal ovaries

S. Chu1,2, S. Rushdi1, E.T. Zumpe1, P. Mamers2, D.L. Healy2, T. Jobling2, H.G. Burger1 and P.J. Fuller1,3

1 Prince Henry's Institute of Medical Research and the 2 Monash University Departments of Medicine and Obstetrics & Gynaecology, Monash Medical Centre, Clayton, Victoria, 3168, Australia

Development, growth and function of the ovary are controlled by endocrine and paracrine signals. These may also influence the development of ovarian cancer. The aim of this study was to identify the key molecular markers of the unregulated growth and hormone synthesis seen in ovarian tumours, particularly in granulosa cell tumours (GCT). Genes used in this study were chosen on the basis of our understanding of growth and differentiation in the normal ovary. We sought to define the patterns of gene expression in a panel of epithelial and stromal ovarian tumours. Expression was determined by RT–PCR using gene-specific primers for the FSH receptor (FSHR); the FSH early response genes: regulatory subunit of protein kinase A (RII-ß), cyclin D2 (cycD2) and sgk; and late response markers: cyclooxygenase-2 (COX-2) and the LH receptor (LHR). The GCT had high expression of FSHR compared with normal ovaries and the other tumours. cycD2 and RII-ß and COX-2 genes were also highly expressed in the GCT. sgk and LHR expression was lower in all of the tumours than in normal ovaries. Serous cystadenocarcinomas also had an unexpectedly high expression of COX-2. Comparison of the gene expression profiles between each tumour group suggests a molecular phenotype for GCT that is similar to that reported for FSH stimulated pre-ovulatory granulosa cells.

epithelial tumours/FSH receptor/granulosa cell tumours/LH receptor

3 To whom correspondence should be addressed at: Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Victoria 3168, Australia. E-mail: peter.fuller{at}med.monash.edu.au


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