Molecular Human Reproduction, Vol. 8, No. 6, 574-579,
June 2002
© 2002 European Society of Human Reproduction and Embryology
Implantation and pregnancy |
PPAR
expression in normal human placenta, hydatidiform mole and choriocarcinoma
1 Institutes of Normal Human Morphology, 2 Clinical Medicine, 3 Pathological Anatomy and Histology, Faculty of Medicine, University of Ancona, Ancona, 4 Department of Obstetrics and Gynaecology, University of Torino, Torino, Italy and 5 Centre Hospitalier Universitaire Vaudois, Laboratoire de Rhumatologie, Nestlé 05–5029, 1011 Lausanne, Switzerland
Peroxisome proliferator-activated receptor (PPAR) 
belongs to a subclass of nuclear hormone receptors that execute their transcriptional functions as heterodimers with the retinoid X receptors (RXR). PPAR plays a pivotal role in cellular differentiation. This study investigated PPAR protein expression in normal human placentas, hydatidiform moles and choriocarcinoma, using immunohistochemical and Western blot analyses. In first trimester normal placenta, PPAR was mainly localized in the nuclei of the villous cytotrophoblastic cells, whereas at term it was mainly localized in the nuclei of the syncytiotrophoblast. Extravillous cytotrophoblast of cell islands and cell columns also showed nuclear PPAR immunostaining. A striking result was the altered expression patterns of PPAR in pathological tissues; PPAR showed a reduced immunostaining in the trophoblastic diseases. In hydatidiform moles, PPAR was mainly localized in the nuclei of the trophoblastic collections of the pathological villi and in the extravillous trophoblastic cells, whereas in the choriocarcinoma, only a few trophoblastic cells showed weak PPAR nuclear immunostaining. These findings suggest an involvement of PPAR in trophoblast differentiation during normal placental development. The down-regulation of PPAR expression in the gestational trophoblastic diseases analysed in this study provides a new insight into the progression of these pathologies.
choriocarcinoma/hydatidiform mole/placenta/PPAR
6 To whom correspondence should be addressed at: Institute of Normal Human Morphology–Anatomy, Faculty of Medicine, University of Ancona, Via Tronto, 10/A, I-60020 Ancona, Italy. E-mail: lorenag23{at}libero.it
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. J Holdsworth-Carson, M. Permezel, G. E Rice, and M. Lappas Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor Reproduction, June 1, 2009; 137(6): 1007 - 1015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P M Chiu, H C Feng, D M Benbrook, H Y S Ngan, U S Khoo, W C Xue, S W Tsao, K W Chan, and A N Y Cheung Effect of all-trans retinoic acid on tissue dynamics of choriocarcinoma cell lines: an organotypic model J. Clin. Pathol., August 1, 2006; 59(8): 845 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Rodie, A. Young, F. Jordan, N. Sattar, I. A. Greer, and D. J. Freeman Human Placental Peroxisome Proliferator-Activated Receptor {delta} and {gamma} Expression in Healthy Pregnancy and in Preeclampsia and Intrauterine Growth Restriction Reproductive Sciences, July 1, 2005; 12(5): 320 - 329. [Abstract] [PDF]
|
|
|
|
 |
|
 L. L. Waite, R. E. Louie, and R. N. Taylor Circulating Activators of Peroxisome Proliferator-Activated Receptors Are Reduced in Preeclamptic Pregnancy J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 620 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Han, N. Sidell, P. B. Fisher, and J. Roman Up-regulation of p21 Gene Expression by Peroxisome Proliferator-Activated Receptor {gamma} in Human Lung Carcinoma Cells Clin. Cancer Res., March 15, 2004; 10(6): 1911 - 1919. [Abstract] [Full Text] [PDF]
|
|