Molecular Human Reproduction, Vol. 8, No. 8, 719-721,
August 2002
© 2002 European Society of Human Reproduction and Embryology
Testis and spermatogenesis |
Can mitochondrial DNA mutations cause sperm dysfunction?
1 Departments of Reproductive Medicine and 2 Neurology, The University of Newcastle-upon-Tyne, UK
Very low levels of somatic mitochondrial (mt)DNA deletions have been identified in the semen of infertile men. It has been suggested that these mutations cause infertility through an effect on sperm motility, but there has been no direct evidence to show that mutant mtDNA can affect sperm function. We have carried out semen analysis on a male harbouring the A3243G mtDNA mutation and show that high levels of mutant mtDNA strongly correlate with low sperm motility.
infertility/MELAS/mitochondrial encephalomyopathy/mtDNA/sperm
3 To whom correspondence should be addressed at: Department of Neurology, The Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK. E-mail: p.f.chinnery{at}ncl.ac.uk
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