Molecular Human Reproduction, Vol. 9, No. 1, 47-52,
January 2003
© 2003 European Society of Human Reproduction and Embryology
Article |
Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms in endometriosis
Submitted on July 22, 2002; accepted on August 16, 2002
1 Molecular Biology Laboratory, Istituto Auxologico Italiano, V.le Monte Nero 32, 20135 Milan and 2 II Department of Obstetrics and Gynecology, University of Milan, School of Medicine, Milan, Italy 3 To whom correspondence should be addressed. e-mail: a.diblasio{at}auxologico.it
Endometriosis is a gynaecological disease with a certain genetic background, but the locations of possible genomic aberrations are still poorly clarified. Intercellular adhesion molecule-1 (ICAM-1), which is a surface glycoprotein that promotes adhesion in immunological and inflammatory reactions, seems to play a role in this condition. The aim of this study was to examine the potential associations of ICAM-1 gene polymorphisms with endometriosis and its severity. Specifically, we have studied two polymorphic sites located in codons 241 (G/R241) and 469 (E/K469) of the ICAM-1 gene. Three hundred and sixty-three Italian Caucasian women of reproductive age who underwent laparoscopy for benign pelvic conditions were enrolled in the study. Endometriosis was documented and staged in 188 women while 175 subjects, in whom endometriosis was laparoscopically ruled out, served as the control group. The frequency of the R241 allele was only marginally higher in endometriosis patients than in controls [5.8 versus 2.9%, P = 0.05; odds ratio (OR), 2.1; 95% confidence interval (CI), 1–4.5]. However, a strikingly high frequency of this allele was found in patients with Stage IV endometriosis versus controls (8.6 versus 2.8%, P = 0.008; OR, 3.2; 95% CI, 1.3–7.9). In contrast, the allele and genotype frequencies of the E/K469 polymorphism did not differ significantly between endometriosis and control groups. While the functional correlate of the G/R241 polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain may contribute to the susceptibility to endometriosis.
Key words: endometriosis/ICAM-1/polymorphism
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C.B. Tempfer, M. Simoni, B. Destenaves, and B.C.J.M. Fauser Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis Hum. Reprod. Update, January 1, 2009; 15(1): 97 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Montgomery, D. R. Nyholt, Z. Z. Zhao, S. A. Treloar, J. N. Painter, S. A. Missmer, S. H. Kennedy, and K. T. Zondervan The search for genes contributing to endometriosis risk Hum. Reprod. Update, September 1, 2008; 14(5): 447 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Z. Zhao, D. R. Nyholt, L. Le, S. Thomas, C. Engwerda, L. Randall, S. A. Treloar, and G. W. Montgomery Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample Hum. Reprod., September 1, 2007; 22(9): 2389 - 2397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. A. F. van Kaam, A. Romano, G. A. J. Dunselman, and P. G. Groothuis Transforming Growth Factor {beta}1 Gene Polymorphism 509C/T in Deep Infiltrating Endometriosis Reproductive Sciences, May 1, 2007; 14(4): 367 - 373. [Abstract] [PDF]
|
|
|
|
|
|
K. T. Zondervan, S. A. Treloar, J. Lin, D. E. Weeks, D. R. Nyholt, J. Mangion, I. J. MacKay, L. R. Cardon, N. G. Martin, S. H. Kennedy, et al. Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15 Hum. Reprod., March 1, 2007; 22(3): 717 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.J.A.F. van Kaam, A. Romano, J.P. Schouten, G.A.J. Dunselman, and P.G. Groothuis Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosis Hum. Reprod., January 1, 2007; 22(1): 129 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Achache and A. Revel Endometrial receptivity markers, the journey to successful embryo implantation Hum. Reprod. Update, November 1, 2006; 12(6): 731 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamashita, S. Yoshida, S. Kennedy, N. Ohara, S. Motoyama, and T. Maruo Association Study of Endometriosis and Intercellular Adhesion Molecule-1 (ICAM-1) Gene Polymorphisms in a Japanese Population Reproductive Sciences, May 1, 2005; 12(4): 267 - 271. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Lattuada, P. Vigano, E. Somigliana, A. Abbiati, M. Candiani, and A.M. Di Blasio Analysis of the codon 72 polymorphism of the TP53 gene in patients with endometriosis Mol. Hum. Reprod., September 1, 2004; 10(9): 651 - 654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Varma, T. Rollason, J. K Gupta, and E. R Maher Endometriosis and the neoplastic process Reproduction, March 1, 2004; 127(3): 293 - 304. [Abstract] [Full Text] [PDF]
|
|