Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kanamori, T.
Right arrow Articles by Fujii, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kanamori, T.
Right arrow Articles by Fujii, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Human Reproduction, Vol. 9, No. 11, 709-717, November 2003
© 2003 European Society of Human Reproduction and Embryology

Article

PEP-19 overexpression in human uterine leiomyoma

Submitted on May 23, 2003; resubmitted on July 13, 2003. accepted on July 28, 2003

Takanobu Kanamori1,2, Kenji Takakura1, Masaki Mandai1, Masatoshi Kariya1, Ken Fukuhara1,2, Takashi Kusakari1, Chika Momma1, Hiroaki Shime1, Haruhiko Yagi1, Mitsunaga Konishi1, Ayako Suzuki1, Noriomi Matsumura1, Kanako Nanbu1, Jun Fujita2 and Shingo Fujii1,3

1 Department of Gynecology and Obstetrics and 2 Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto, 606-8507, Japan

3 To whom correspondence should be addressed at: Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, 54, Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan. e-mail: sfu{at}kuhp.kyoto-u.ac.jp

Although uterine leiomyomas represent one of the most common neoplasms in adult women, their pathogenesis remains poorly understood. A cDNA microarray analysis was performed to search for candidate genes expressed to a greater degree in leiomyoma compared with matched myometrium. A total of 15 candidate genes was obtained; neuron-specific protein PEP-19 (Purkinje cell protein 4; PCP 4) exhibited a striking difference in expression between leiomyoma and myometrium. Although PEP-19 expression has been reported exclusively in the central nervous system, the present study demonstrated that PEP-19 is also expressed in other human organs, including prostate, kidney and uterus. To clarify the role of PEP-19 in the pathogenesis of leiomyomas, PEP-19 expression was investigated for a series of human leiomyoma, as well as normal myometrium and leiomyosarcoma. PEP-19 mRNA and protein expression were much stronger in leiomyomas compared with normal myometrium, suggesting that PEP-19 might be involved in leiomyoma pathogenesis.

Key words: microarray/northern blot analysis/PEP-19/uterine leiomyoma


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ReproductionHome page
C. P Read, R A. Word, M. A Ruscheinsky, B. C Timmons, and M. S Mahendroo
Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice
Reproduction, August 1, 2007; 134(2): 327 - 340.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Matsumura, M. Mandai, M. Miyanishi, K. Fukuhara, T. Baba, T. Higuchi, M. Kariya, K. Takakura, and S. Fujii
Oncogenic Property of Acrogranin in Human Uterine Leiomyosarcoma: Direct Evidence of Genetic Contribution in In vivo Tumorigenesis
Clin. Cancer Res., March 1, 2006; 12(5): 1402 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
T. Kanamori, K. Takakura, M. Mandai, M. Kariya, K. Fukuhara, M. Sakaguchi, N.-h. Huh, K. Saito, T. Sakurai, J. Fujita, et al.
Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours
Mol. Hum. Reprod., October 1, 2004; 10(10): 735 - 742.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.