Molecular Human Reproduction, Vol. 9, No. 2, 75-80,
February 2003
© 2003 European Society of Human Reproduction and Embryology
Article |
Expression and function of interleukin-11 and its receptor 
in the human endometrium
Submitted on June 11, 2002; resubmitted on August 20, 2002. accepted on November 13, 2002
1 Department of Obstretrics and Gynaecology, University of Oxford, Women’s Centre, Level 3, John Radcliffe Hospital, Oxford OX3 9DU and 2 Cancer Research Campaign Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
3 To whom correspondence should be addressed. e-mail: helen.mardon{at}obs-gyn.ox.ac.uk
The interleukin-11 (IL-11) receptor 
has an important function in decidualization of mouse endometrial stroma but the function of IL-11 and its receptor in the human endometrium remains unknown. The mRNA for IL-11 and its receptor in human endometrial tissue samples were analysed by semi-quantitative RT–PCR and RNase protection assays respectively. The proteins were detected in frozen endometrial tissue samples by immunofluorescence. The effect of heparin-binding epidermal growth factor (HB-EGF) on secretion of IL-11 by cultured endometrial stromal cells was assessed by enzyme-linked immunosorbent assay. The proliferative potential of IL-11 in endometrial stromal cells was assessed by [3H]thymidine uptake. IL-11 and its receptor mRNAs and proteins were detected in the endometrium throughout the cycle. Distinct patterns of localization of the ligand and receptor were observed. HB-EGF induced IL-11 secretion by cultured stromal cells, and IL-11 induced [3H]thymidine uptake by these cells. Our data suggest that IL-11–receptor interactions may perform different functions in the human endometrium at different stages of the cycle, and that secretion of IL-11 is modulated by local growth factors.
Key words: endometrium/heparin-binding epidermal growth factor/interleukin-11/interleukin-11 receptor /proliferation
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