Molecular Human Reproduction, Vol. 9, No. 3, 165-169,
March 2003
© 2003 European Society of Human Reproduction and Embryology
Article |
Glutathione S-transferase M1 and T1 polymorphisms and the risk of recurrent pregnancy loss
Submitted on May 31, 2002; resubmitted on August 29, 2002. accepted on December 13, 2002
1 Department of Public Heath, Hokkaido University Graduate School of Medicine and 2 Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan
3 To whom correspondence should be addressed. e-mail: fsata{at}med.hokudai.ac.jp
The aetiology of recurrent pregnancy loss (RPL) remains unclear, but it may be related to a possible genetic predisposition together with involvement of environmental factors. We examined the relation between RPL and polymorphisms in two genes, glutathione S-transferases (GST) M1 and T1, which are involved in the metabolism of a wide range of environmental toxins and carcinogens. A case–control study of 115 cases with RPL and 160 controls was conducted. All cases and controls were women resident in Sapporo, Japan and the surrounding area. They were genotyped for polymorphisms of GSTM1 and GSTT1 using PCR-based methods. We found that 65.2% of the cases with RPL and 45.6% of the controls had the GSTM1 null genotype [odds ratio (OR) = 2.23, 95% confidence interval (CI) = 1.36–3.66]. On the other hand, 47.0% of the cases and 49.4% of the controls had the GSTT1 null genotype (OR = 0.95; 95% CI = 0.58–1.55). The results suggest that women with GSTM1 null polymorphism may therefore have an increased risk of RPL.
Key words: genetic polymorphism/glutathione S-transferase M1/glutathione S-transferase T1/molecular epidemiology/recurrent pregnancy loss
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