Molecular Human Reproduction, Vol. 9, No. 8, 491-495,
August 2003
© 2003 European Society of Human Reproduction and Embryology
Article |
Evaluation of germline sequence variants within the promoter region of RANTES gene in a cohort of women with endometriosis from Spain
Submitted on March 4, 2003; accepted on April 14, 2003
1 Unidad de Genética Médica y Diagnóstico Prenatal, 2 Unidad de Reproducción and 3 Servicio de Ginecología, Hospitales Universitarios Virgen del Rocío, Avda. Manuel Siurot s/n. 41013, Seville, Spain
4 To whom correspondence should be addressed. e-mail: guillermo.antinolo.sspa{at}juntadeandalucia.es
The RANTES (regulated upon activation normal T cells expressed and secreted) chemokine, is known to be expressed in endometriotic lesions in a concentration correlating with the severity of endometriosis. Since it has been widely demonstrated that endometriosis has a genetic basis, we postulated that the gene encoding RANTES could be a good candidate gene for the disease. We have used fluorescence resonance energy transfer (FRET) technology to genotype and evaluate the role of the variants –403G
A and –28CG, located within the promoter region of the gene, as susceptibility factors in a cohort of Spanish women with endometriosis. No differences have been found in the allelic frequencies of both variants nor in the haplotype/ genotype distribution between patients and controls. These data are consistent with the lack of association between these polymorphisms and endometriosis in our population. They do not exclude completely a possible role of other variants within RANTES gene in this pathology.
Key words: endometriosis/genetics/polymorphisms/RANTES/susceptibility factor
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C.B. Tempfer, M. Simoni, B. Destenaves, and B.C.J.M. Fauser Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis Hum. Reprod. Update, January 1, 2009; 15(1): 97 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Lebovic, V. A. Chao, and R. N. Taylor Peritoneal Macrophages Induce RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) Chemokine Gene Transcription in Endometrial Stromal Cells J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1397 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Antinolo, R.M. Fernandez, J.A. Noval, J.L. Molini, and S. Borrego Analysis of the involvement of CCR5-{Delta}32 and CCR2-V64I variants in the development of endometriosis Mol. Hum. Reprod., March 1, 2004; 10(3): 155 - 157. [Abstract] [Full Text] [PDF]
|
|