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Mol. Hum. Reprod. Advance Access published online on August 31, 2009
Molecular Human Reproduction, doi:10.1093/molehr/gap076
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Effects of highly purified urinary FSH and human menopausal FSH on Uterine Myoelectrical Dynamics

Seyma Hascalik, MDa,A,B,C,D,E, Onder Celik, MDa,A,B,C,D,E, M.Emin Tagluk, PhDb,A,B,D,E, Ayse Yildirim, MDc,D,F and N.Engin Aydin, MDd,D,F

aDepartment of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya bDepartment of Electric and Electronic Engineering, Inonu University, Malatya cDepartment of Histology and Embryology, MKU University School of Medicine, Antakya, Turkey dDepartment of Pathology, Inonu University School of Medicine, Malatya

Correspondence to: Seyma HASCALIK, MD, Inonu University, Turgut Ozal Medical Center, Department of Obstetrics and Gynecology, 44069, Malatya, Turkey, E-mail: shascalik{at}inonu.edu.tr, Fax: +90 422 341 0728, Phone: +90 422 341 0660

The aim of the study was to investigate the effects of urinary FSH compounds on the electrical activity of myometrium using signal-processing techniques. Thirty animals were involved in the experiment. After two successive normal estrous cycles, 15 of these animals were put into three equal subgroups. Group 1 was the control; animals were given solvent. Groups 2 and 3 were treated with Urofollitropin and Menotropin, respectively. The other 15 animals were ovariectomized and subjected to the same protocol. Their uterine myoelectrical signals were recorded over a period of at least three minutes at a sampling frequency of 500 Hz, and analyzed through software assisted signal processing. The results show the power and some characteristic spectral components of myoelectrical signal were differentially reduced with the administration of highly purified urinary FSH and human menopausal FSH but significant differences were not detected between their histology. In conclusion, uterine myoelectrical signals change with administration of urinary FSH preparations. Human menopausal FSH and more precisely highly purified FSH suppress the spectral components and modify the power of the myoelectrical signals which provides uterine quiescence.

Key Words: Myoelectrical signal highly purified urinary FSH/human menopausal FSH/Endometrium

A: Study Design

B: Data Collection

C: Statistical Analysis

D: Data Interpretation

E: Manuscript Preparation

F: Histological evaluation

Submitted on January 7, 2009; resubmitted on July 22, 2009; accepted on August 24, 2009.


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