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Mol. Hum. Reprod. Advance Access published online on September 3, 2009
Molecular Human Reproduction, doi:10.1093/molehr/gap078
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Elevated levels of oxidised low-density lipoprotein and of catalase activity in follicular fluid of obese women

J. Bausenwein*,1, H. Serke*,1, K. Eberle1, J. Hirrlinger2, P. Jogschies3, F.A. Hmeidan3, V. Blumenauer3 and K. Spanel-Borowski**,1

1 Institute of Anatomy, University of Leipzig, Leipzig, Germany 2The Interdisciplinary Center of Clinical Research (IZKF) Leipzig at the Faculty of Medicine of the University of Leipzig, Inselstrasse 22, 04103 Leipzig, Germany 3Clinic for Reproductive Medicine and Gynecological Endocrinology, Goldschmidtstrasse 30, Leipzig, Germany

** Correspondence should be addressed at: K. Spanel-Borowski, Institute of Anatomy, University of Leipzig, Liebigstraße 13, D-04103 Leipzig, Germany. Phone +49 341-9722000, Fax +49 341-97 22009. E-mail: spanelb{at}medizin.uni-leipzig.de

The intrafollicular levels of oxidised low-density lipoprotein (oxLDL) and of enzyme antioxidants might contribute to reproductive disorders in obese and infertile women. Relevant data are missing. Eighty-four patients were grouped according to obese versus non-obese status and whether they had polycystic ovary syndrome (PCOS). The concentrations of oxLDL and the activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione reductase (GR) in serum and follicular fluid (FF) were measured. Obese women with and without PCOS had significantly greater amounts of oxLDL in FF as compared to non-obese women. The level of oxLDL in FF was 1000-times lower than in serum. Obese women with and without PCOS had significantly higher catalase activity in FF as compared to non-obese women. No differences were found for SOD activity in FF. The GPx and GR acitivities were up-regulated in obese patients without and with PCOS, yet not in respect to each serum and FF sample. We conclude that elevated levels of oxLDL in the FF of obese women are associated with higher catalase activity; both parameters are independent of PCOS. The levels of oxLDL and catalase activity appear to indicate different degrees of oxidative stress.

Key Words: oxidised low-density lipoprotein/follicular fluid;/obesity/PCOS, catalase activity

* co-first authors

Submitted on July 30, 2009; resubmitted on August 27, 2009; accepted on September 1, 2009.


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