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Mol. Hum. Reprod. Advance Access published online on October 9, 2009
Molecular Human Reproduction, doi:10.1093/molehr/gap088
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Nucleolar transplantation in oocytes and zygotes: challenges for further research

Helena Fulka1 and Josef Fulka, Jr1

1 Institute of Animal Science, Prague, Czech Republic

Correspondence: Josef Fulka, Jr., Institute of Animal Science, Pratelstvi 815, CS-104 00 Prague 10, Czech Republic, Phone: +420 267 009 606, Fax: +420 267 710 779, E-mail: fulka{at}vuzv.cz

In germinal vesicles (GVs) of immature mammalian oocytes, including humans, as well as in pronuclei in one-cell stage embryos, prominent nuclear organelles – nucleoli, can be easily detected even under a relatively low magnification. In humans, it has been clearly documented that their number, position and distribution in pronuclei can be used as an indicator of embryonic developmental potential. In the light of some recent experiments showing the feasibility of nucleolar manipulation we discuss here if these new approaches can be used to rescue those embryos with abnormal pronuclear nucleolar patterns.

Key Words: oocytes/zygotes/pronuclei/nucleolus

Submitted on August 20, 2009; resubmitted on September 29, 2009; accepted on October 7, 2009.


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