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Molecular Human Reproduction, Vol. 6, No. 2, 197-198, February 2000
© 2000 European Society of Human Reproduction and Embryology

Letters to the editor

Hypothesis testing by X chromosome inactivation patterns may be more informative with lineage-specific cells

Timothy H.J. Florin and Debra Taylor

Associate Professor of Medicine, University of Queensland, Department of Medicine, Mater Adult Hospital, South Brisbane, Queensland 4101, Australia Research Officer, Leukemia Laboratory, Mater Adult Hospital, South Brisbane, Queensland 4101, Australia

Dear Sir,

Fisk et al. (1999) have postulated that twin–twin transfusion syndrome (TTTS), which only occurs in monochorionic diamniotic twin pregnancies, could arise from asymmetry of the splitting of the inner cell mass which forms the twins. The timing of the splitting of the inner cell mass occurs around the same time as the X chromosome inactivation process (Lyonization). In their interesting paper, Fisk et al. used X chromosome inactivation patterns to test their hypothesis that asymmetric splitting predisposes to TTTS. However, they found that TTTS was not significantly associated with skewing of the . . . [Full Text of this Article]

References

Nicholas M. Fisk and Phillip R. Bennett

Department of Maternal and Fetal Medicine, Imperial College School of Medicine, Queen Charlotte's & Chelsea Hospital, Goldhawk Road, London W6 OXG, UK


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