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Molecular Human Reproduction, Vol. 7, No. 7, 691-693, July 2001
© 2001 European Society of Human Reproduction and Embryology

Letter to the editor

The role of USP9Y and DBY in infertile patients with severely impaired spermatogenesis

L. Van Landuyt1,3, W. Lissens2, K. Stouffs2, H. Tournaye1, A. Van Steirteghem1, I. Liebaers2, O. Blagosklonova and J-L. Bresson

1 Centre for Reproductive Medicine and 2 Centre for Medical Genetics, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Laarbeeklaan 101, B-1090 Brussels, Belgium Laboratoire de Génétique, Biologie du Développement et de la Reproduction, EA 3185, Genetique et Reproduction, Faculte de Medecine et de Pharmacie. Place Saint-Jacques, 25030, Besancion Cedex, France

Dear Sir,

Our attention was drawn to the article by Blagosklonova et al. (2000) in which Yq microdeletions were investigated retrospectively by performing PCR on DNA extracted from archival sections of testicular biopsies. We were very surprised at the high number of USP9Y (formerly known as DFFRY) deletions found in patients with Sertoli cell-only syndrome (SCOS) (4/22) and we thought it would be worthwhile to check this in our own population of azoospermic patients with primary testicular dysfunction.

We therefore analysed 69 subjects with complete SCOS (SCO type I, complete absence of germ cells) and 17 patients . . . [Full Text of this Article]

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