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Molecular Human Reproduction 2008 14(12):679-690; doi:10.1093/molehr/gan066
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
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This article appears in the following Molecular Human Reproduction issue: Special Issue: Emerging Technologies for the Assessment of Gametes and Embryos - The OMICS [View the issue table of contents]

Metabolomics and its application for non-invasive embryo assessment in IVF

Lucy Botros1, Denny Sakkas2,3 and Emre Seli3,4

1 Molecular Biometrics LLC, Montreal, Quebec, Canada 2 Molecular Biometrics LLC, New Haven, CT, USA 3Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 300 George Street, Suite 770J, New Haven, CT 06511, USA

4 Correspondence address. Fax: +1-203-785-7134; E-mail: emre.seli{at}yale.edu

Morphology and cleavage rate remain the mainstay of embryo assessment. However, a number of additional technologies for this application are under investigation. These include the measurement of glucose, lactate, pyruvate or amino acid levels in the embryo culture media, assessment of oxygen consumption by the embryo, genomic and proteomic profiling, and most recently, analytical examination of the embryonic metabolome. As the number of assisted reproduction cycles increases worldwide, improvements in the ability to quickly and non-invasively identify the best embryos for transfer remain a critical goal for reproductive medicine. Recent studies suggest that metabolomic profiling of embryo culture media using optical and non-optical spectroscopies may provide a useful adjunct to the current embryo assessment strategies and provide insight into the phenotype of embryos with increasing reproductive potential.

Key words: metabolomics/in vitro fertilization/non-invasive embryo assessment

Submitted on September 8, 2008; resubmitted on October 31, 2008; accepted on November 4, 2008.


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