Molecular Human Reproduction, Vol 3, 27-45, Copyright © 1997 by Oxford University Press
DL Hulboy, LA Rudolph and LM Matrisian
The organs of the adult reproductive system can undergo extensive
remodelling, experiencing rapid changes in tissue mass and function. Much
of this matrix remodelling is attributed to the action of matrix
metalloproteinases. Matrix metalloproteinase family members are expressed
in a highly-regulated manner in many reproductive processes, including
menstruation, ovulation, implantation, and uterine, breast, and prostate
involution. Metalloproteinase concentrations and activity can be regulated
by reproductive hormones, as well as by growth factors and cytokines that
participate in reproductive events. In addition to playing a role in the
loss of connective tissue mass, the metalloproteinases can influence the
phenotype of the cellular components of the tissues, altering basic
cellular functions such as proliferation, differentiation, and apoptosis.
This review focuses on the expression of matrix metalloproteinases in
reproductive tissues, and discusses the evidence supporting a role for
these enzymes in modulating the structure and function of reproductive
organs.
REVIEW, TUTORIAL
Matrix metalloproteinases as mediators of reproductive function
Department of Cell Biology, Vanderbilt University, Nashville, TN 37232, USA.
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