Molecular Human Reproduction, Vol 3, 919-925, Copyright © 1997 by Oxford University Press
K Hardy
Cell death is a widespread feature in the blastocysts of many mammals.
Isolated cells in both the inner cell mass and the trophectoderm undergo
cell death. These dying cells appear morphologically to be undergoing
apoptosis. In mouse blastocysts, a wave of cell death is seen in vivo,
suggesting that it plays an important role in normal development. However,
cell death is increased under suboptimal culture conditions. There is
evidence that levels of cell death are regulated by 'survival' factors
produced both by the embryo itself and by the maternal reproductive tract.
The role of cell death in development is unknown, but could involve the
elimination of abnormal cells, or a sublineage of cells with an
inappropriate developmental potential. Work in other systems has
demonstrated that cell death is regulated by the activity of apoptosis
genes. Whether these genes are implicated in blastocyst cell death, and the
reasons for apoptosis in the early embryo, remain to be determined.
REVIEW, TUTORIAL
Cell death in the mammalian blastocyst
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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