Molecular Human Reproduction, Vol 3, 467-472, Copyright © 1997 by Oxford University Press
JA Cioffi, J Van Blerkom, M Antczak, A Shafer, S Wittmer and HR Snodgrass
The expression of leptin and its receptors was examined by reverse
transcriptase-polymerase chain reaction and immunofluorescence in granulosa
and cumulus cells of pre-ovulatory follicles and in meiotically mature
oocytes obtained from women undergoing in-vitro fertilization. Leptin
concentrations were measured in newly aspirated follicular fluids and in
maternal serum before and after the administration of an ovulatory dose of
human chorionic gonadotrophin. The findings demonstrate leptin expression
at the mRNA and protein levels by granulosa and cumulus cells, and the
presence of leptin in mature human oocytes. While an association between
follicular leptin concentration and embryo development was not observed, a
post-ovulatory increase in serum leptin concentration was associated with
implantation potential. The results are discussed with respect to possible
roles of leptin in early human development.
JOURNAL ARTICLE
The expression of leptin and its receptors in pre-ovulatory human follicles
Progenitor Inc, Columbus Ohio 43212, USA.
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