Molecular Human Reproduction, Vol 3, 473-478, Copyright © 1997 by Oxford University Press
JA Kramer and SA Krawetz
The presence of specific messenger RNAs in the nuclei of mature mammalian
spermatozoa has been demonstrated by several independent laboratories.
Others have suggested that various polymerases may also be active in mature
spermatozoa. This has led to the notion that the 'sleeping' genome may not
be so quiescent after all. The alternate use of somatic-like nucleosomal
and haploid protamine packaging structures to assemble sperm chromatin and
the ordered array of chromosomes within the mature human sperm nucleus
support this view. This had led us to address the issue of whether a
somatic-like organization of select regions of the paternal genome and the
mRNAs present in spermatozoa were correlated. Results from this and other
laboratories suggest that this in indeed the case. Potential roles for this
novel packaging and the accumulation of transcripts within the mature human
nucleus are discussed.
REVIEW, TUTORIAL
RNA in spermatozoa: implications for the alternative haploid genome
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48102, USA.
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