Molecular Human Reproduction, Vol 3, 479-483, Copyright © 1997 by Oxford University Press
C Carani, J Gromoll, MH Brinkworth, M Simoni, GF Weinbauer and E Nieschlag
A gene on the human Y chromosome, specifically deleted in azoospermic
patients (DAZ: deleted in azoospermia), and a DAZ homologue (DAZH) on human
chromosome 3, have been recently described. In the present work we report
the isolation and characterization of the corresponding DAZH gene of the
cynomolgus monkey (Macaca fascicularis), which we have named cynDAZLA
(cynomolgus DAZ-like autosomal). Reverse transcription- polymerase chain
reaction was used to amplify the monkey DAZ homologue, and sequence
analysis revealed an open reading frame of 888 bp encoding 295 amino acids.
Northern blot hybridization of different tissues to a probe derived from
the cynDAZLA cDNA detected a transcript of 3.5 kb that, in the male, was
expressed only in the testis. Comparison of the cynDAZLA sequence to
autosomal DAZ homologues from human, mouse and Drosophila showed two
RNA-recognition motifs (RRM) and the presence of only one DAZ consensus
repeat compared with the seven repeats found in the human DAZ gene on the Y
chromosome. The homology of the cynDAZLA cDNA compared with the human DAZH
and mouse dazla cDNAs is 97.97 and 87.46% respectively. The identification
of the monkey cynDAZLA enables further studies regarding the putative
functions of DAZH, such as onset of expression and hormonal dependence of
this gene.
JOURNAL ARTICLE
cynDAZLA: a cynomolgus monkey homologue of the human autosomal DAZ gene
Chair of Endocrinology, University of Modena, Italy.
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