Molecular Human Reproduction, Vol 4, 27-32, Copyright © 1998 by Oxford University Press
FE Rodger, HM Fraser, S Krajewski and PJ Illingworth
The mechanisms of luteal maintenance and regression in women are uncertain,
but morphological and oligonucleosome studies raise the possibility that
apoptosis may be involved. BAX is a proto-oncogene of the BCL-2 family
which can induce apoptosis. The aim of this study was to determine whether
BAX is expressed in the human corpus luteum and whether the level of
expression changes relative to the stage of the luteal phase or in
simulated early pregnancy. Carefully timed samples of corpus luteum were
studied by immunostaining, sodium dodecyl sulphate-polyacrylamide gel
electrophoresis and immunoblotting. BAX protein was immunolocalized in
luteal sections from all stages including luteal rescue but BAX production
did not change during luteal maintenance or regression. Localization of BAX
to the steroid-secreting cells of the corpus luteum implies a functional
role and BAX may interact with other members of the BCL-2 family to affect
luteal function.
JOURNAL ARTICLE
Production of the proto-oncogene BAX does not vary with changing in luteal function in women
MRC Reproductive Biology Unit, Edinburgh, UK.
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