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Molecular Human Reproduction, Vol. 6, No. 11, 973-975, November 2000
© 2000 European Society of Human Reproduction and Embryology

Testis and spermatogenesis

CAG repeat length of the androgen receptor gene in Japanese males with cryptorchidism

Isoji Sasagawa1,3, Yasuhiro Suzuki1, Tadashi Tateno1, Teruhiro Nakada1, Koji Muroya2 and Tsutomu Ogata2

1 Department of Urology, Yamagata University School of Medicine, Yamagata 2 Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

Abstract

We have analysed the CAG repeat length in exon 1 of the androgen receptor gene in 48 Japanese males with cryptorchidism and 100 fertile Japanese males. The CAG repeat length was 23.4 ± 0.48 (mean ± SE) (range 16–32, median 23) in cryptorchid patients and 23.5 ± 0.29 (range 15–32, median 23) in normal males. There was no significant difference between the two groups. The expansion of the CAG repeats in exon 1 of the androgen receptor gene is unlikely to constitute a major cause of cryptorchidism.

androgen receptor/CAG repeat/cryptorchidism

Notes

3 To whom correspondence should be addressed at: Department of Urology, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-shi, Yamagata 990-9585, Japan. E-mail: isasaga{at}med.id.yamagata-u.ac.jp


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