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Molecular Human Reproduction, Vol. 8, No. 6, 540-545, June 2002
© 2002 European Society of Human Reproduction and Embryology

Ovary and oogenesis

Expression of DAZL protein in the human corpus luteum

H.A. Pan1, S.J. Tsai3, C.W. Chen1, Y.C. Lee1, Y.M. Lin2 and P.L. Kuo1,4

1 Departments of Obstetrics and Gynecology, 2 Urology, National Cheng-Kung University Hospital and 3 Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan

The DAZL gene and its homologues are required for the development of male and female germ cells in different species. However, their role in other aspects of human reproduction is not known. We have generated a polyclonal antibody to the DAZL protein and developed a sensitive standard curve quantitative-competitive–RT–PCR assay to characterize the expression of DAZL in the human corpus luteum (CL). DAZL transcripts are expressed in the CL, but the concentrations decreased with advancing luteal phase. In accordance with the mRNA data, DAZL protein was most abundant in the early phase CL. Immunohistochemical staining showed DAZL protein in the cytoplasm of granulosa–luteal cells. The distinct expression pattern of DAZL protein in the human CL may play an important role in the regulation of luteal function.

corpus luteum/DAZL protein/DAZL transcript/granulosa/luteal cell

4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, National Cheng-Kung University Medical Center, 138 Sheng-Li Road, Tainan 70428, Taiwan. E-mail: paolink{at}mail.ncku.edu.tw


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