Mol. Hum. Reprod. Advance Access published online on March 2, 2004
Molecular Human Reproduction, doi:10.1093/molehr/gah048
© 2004 by Oxford University Press
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1 Second Department of Internal Medicine, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece; Patriarhou Grigoriou 97-99, 68100 Alexandroupolis, Greece
* To whom correspondence should be addressed. E-mail: dapap{at} otenet.gr.
Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification.
Revised January 26, 2004
Accepted January 31, 2004
Article
Vascular endothelial growth factor gene polymorphisms and pre-eclampsia
2 Department of Obstetrics and Gynecology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
3 Department of Radiotherapy-Oncology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
4 Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden
5 Second Department of Internal Medicine, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
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