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Mol. Hum. Reprod. Advance Access published online on March 16, 2004
Molecular Human Reproduction, doi:10.1093/molehr/gah049
© 2004 by Oxford University Press
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Received January 25, 2004
Revised February 9, 2004
Accepted February 16, 2004

Article

Aberrant gene expression associated with recurrent pregnancy loss

Kwang-Hyun Baek 1*

1 Cell and Gene Therapy Research Institute, Infertility Medical Center, Pochon CHA University, CHA General Hospital, 605 Yeoksam 1-Dong, Kangnam-Gu, Seoul 135-081, Korea

* To whom correspondence should be addressed. E-mail: baek{at}cha.ac.kr.


  Abstract

Recent studies indicate that a number of factors including chromosomal abnormalities, immunological feto-maternal rejection, hormonal irregulation and anatomical factors are involved in provoking recurrent pregnancy loss (RPL). This indicates that normal cellular regulation of these factors is required for maintaining normal pregnancy. In addition, it is expected that biological processes for maintaining normal pregnancy require a series of differential gene expression. As expected, our previous investigations revealed that there are >=30 genes showing different levels of expression between normal and RPL patients. In addition, other research groups have also identified a number of genes that are expressed aberrantly in pregnancy failure. In this review, recent study on aberrant expression levels of genes, which are grouped as immunity-related, angiogenesis-related, apoptosis-related and other groups of genes, will be discussed.

Key Words: Key words: angiogenesis/apoptosis/immunosuppression/recurrent pregnancy loss


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