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Mol. Hum. Reprod. Advance Access published online on September 24, 2004
Molecular Human Reproduction, doi:10.1093/molehr/gah111
© 2004 by Oxford University Press
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Received June 30, 2004
Accepted September 3, 2004

Article

Chromosome aneuploidy in the spermatozoa of two men with globozoospermia

F. Morel 1 *, N. Douet-Guilbert 1 *, A. Moerman 2, B. Duban 3, C. Marchetti 4, B. Delobel 3, M.-J. Le Bris 5, V. Amice 5, and M. De Braekeleer 1*

1 Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, Brest, France; Service de Cytogénétique, Cytologie et Biologie de la Reproduction, CHU Morvan, Brest, France
2 Service de Génétique Clinique, CHRU, Lille, France
3 Centre de Génétique Chromosomique, Hôpital St Vincent de Paul, Lille, France
4 Service de Biologie de la Reproduction, CHRU, Lille, France
5 Service de Cytogénétique, Cytologie et Biologie de la Reproduction, CHU Morvan, Brest, France

* To whom correspondence should be addressed. E-mail: marc.debraekeleer{at}univ-brest.fr.


  Abstract

The objective of this study was to determine the aneuploidy level in spermatozoa in two men with globozoospermia. Sperm nuclei were analysed by fluorescence in-situ hybridization (FISH) in two infertile males with globozoospermia. Dual FISH for chromosomes 7 and 9, 13 and 21, and triple FISH for chromosomes X, Y, and 18 was performed. The main outcome measured was meiotic segregation differences between both globozoospermic men and controls. A statistically significant difference in disomies 13 and 21 was found between patients 1 and 2. The diploidy rate of spermatozoa of patient 1 (0.876%) was significantly increased compared with that of patient 2 (0.304%) and control men (0.293%). In conclusion there seems to be a slightly increased frequency of aneuploidy in round-headed spermatozoa. However, it is unlikely that these aneuploid spermatozoa would be used in assisted reproduction techniques.

Keywords: cytogenetics; chromosomal abnormality; globozoospermia; meiotic segregation; male infertility; FISH.

*Both authors share first authorship


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