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Mol. Hum. Reprod. Advance Access published online on May 18, 2005
Molecular Human Reproduction, doi:10.1093/molehr/gah182
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Molecular Human Reproduction © The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received April 5, 2005
Accepted April 25, 2005

Article

Tumour necrosis factor-{alpha} gene haplotype is associated with pre-eclampsia

Tanja Saarela 1, Mikko Hiltunen 2, Seppo Helisalmi 2, Seppo Heinonen 1*, and Markku Laakso 3

1 Departments of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland
2 , Department ofNeurology and Neuroscience, University of Kuopio, Kuopio, Finland
3 , Department ofMedicine, University of Kuopio, Kuopio, Finland

* To whom correspondence should be addressed.
Seppo Heinonen, E-mail: Seppo.Heinonen{at}kuh.fi


  Abstract

We determined whether polymorphisms in the promoter region of the tumour necrosis factor alpha (TNF-{alpha}) gene contributes to differences in susceptibility to develop pre-eclampsia. The study involved 133 pre-eclamptic and 115 healthy pregnant women who were genotyped for the G-308A polymorphism of the TNF-{alpha} gene. The frequency of the G-308A allele was more common in the pre-eclampsia group than among the controls (P=0.046), giving an odds ratio of 0.57 (95% CI: 0.32-0.99), but there were no differences in the genotype distribution. The data from the G-308A polymorphism was combined with the previously published genotype and allele data from the C-850T polymorphism of the TNF-{alpha} gene, and used to assess a haplotype estimation analysis. Estimated overall pair of loci haplotype frequencies differed significantly between the groups (P=0.023±0.004). In the single haplotype association analysis, the haplotype C-A versus others was over-represented in the pre-eclampsia group (P=0.041±0.003), whereas the haplotype T-G versus others was less common in the pre-eclampsia group (P=0.035±0.003), compared with the controls. In conclusion, the polymorphisms of the TNF-{alpha} gene showed a significant haplotype association with susceptibility to pre-eclampsia in the Finnish population.

Keywords: tumour necrosis factor alpha; polymorphism; pre-eclampsia; haplotype.
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