Skip Navigation



Mol. Hum. Reprod. Advance Access published online on January 3, 2006
Molecular Human Reproduction, doi:10.1093/molehr/gah219
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
11/11/779    most recent
gah219v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Harris, S. E.
Right arrow Articles by Shelling, A. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harris, S. E.
Right arrow Articles by Shelling, A. N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received June 21, 2005
Accepted July 26, 2005

Article

INHA promoter polymorphisms are associated with premature ovarian failure

Sarah E. Harris 1, Ashwini L. Chand 1, Ingrid M. Winship 2, Ksenija Gersak 3, Yoshihiro Nishi 4, Toshihiko Yanase 4, Hajime Nawata 4, and Andrew N. Shelling 1 *

1 Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
2 Department of Molecular Medicine, University of Auckland, Auckland, New Zealand
3 Department of Obstetrics and Gynaecology, University Medical Centre, Ljubljana, Slovenia
4 Department of Medicine and Bioregulatory Science (Third Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

* To whom correspondence should be addressed.
Andrew N. Shelling, E-mail: a.shelling{at}auckland.ac.nz


  Abstract

Inhibin is an important glycoprotein that is involved in folliculogenesis. INHA, the gene encoding the inhibin alpha subunit, was recently proposed as a candidate for premature ovarian failure (POF), a syndrome that leads to the cessation of ovarian function under the age of 40 years. 70 POF patients and 70 controls were screened for the previously identified INHA - 16C>T transition mutation. The T allele was found in 31/70 (44.3%) of controls, but only 18/70 (25.7%) of POF patients. This result indicates that the T allele is significantly underrepresented in the POF patient population (Fisher’s exact test, two-tail: P = 0.033). Sequence analysis of the INHA promoter in 50 POF patients and 50 controls identified a highly polymorphic imperfect TG repeat at approximately -300 bp, that consisted of four common haplotypes (A, B, C and D). The -16T allele is linked to the shortest repeat haplotype (haplotype C). Despite the association between haplotype C and POF, no significant difference was found between the promoter activity of a luciferase reporter construct containing haplotype C, and most of the other haplotypes tested. Interestingly, haplotype B failed to show any promoter activity. We conclude that the inheritance of specific INHA promoter hap-lotypes predispose to the development of premature ovarian failure.

Keywords: infertility/inhibin/polymorphism/ovarian failure/TG repeat.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
A.L. Chand, C.A. Harrison, and A.N. Shelling
Inhibin and premature ovarian failure
Hum. Reprod. Update, September 14, 2009; (2009) dmp031v1.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
E. Zintzaras
Inhibin alpha gene and susceptibility to premature ovarian failure: a data synthesis
Mol. Hum. Reprod., September 1, 2009; 15(9): 551 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
B. Wang, L. Li, F. Ni, J. Song, J. Wang, Y. Mu, X. Ma, and Y. Cao
Mutational analysis of SAL-Like 4 (SALL4) in Han Chinese women with premature ovarian failure
Mol. Hum. Reprod., September 1, 2009; 15(9): 557 - 562.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Corre, J. Schuettler, S. Bione, A. Marozzi, L. Persani, R. Rossetti, F. Torricelli, I. Giotti, P. Vogt, D. Toniolo, et al.
A large-scale association study to assess the impact of known variants of the human INHA gene on premature ovarian failure
Hum. Reprod., August 1, 2009; 24(8): 2023 - 2028.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Kang, S. K. Lee, M.-H. Kim, J. Song, S. J. Bae, N. K. Kim, S.-H. Lee, and K. Kwack
Parathyroid hormone-responsive B1 gene is associated with premature ovarian failure
Hum. Reprod., June 1, 2008; 23(6): 1457 - 1465.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Tsigkou, S. Marzotti, L. Borges, A. Brozzetti, F. Reis, P. Candeloro, M. Luisa Bacosi, V. Bini, F. Petraglia, and A. Falorni
High Serum Inhibin Concentration Discriminates Autoimmune Oophoritis from Other Forms of Primary Ovarian Insufficiency
J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1263 - 1269.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
B. Mandon-Pepin, P. Touraine, F. Kuttenn, C. Derbois, A. Rouxel, F. Matsuda, A. Nicolas, C. Cotinot, and M. Fellous
Genetic investigation of four meiotic genes in women with premature ovarian failure
Eur. J. Endocrinol., January 1, 2008; 158(1): 107 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Z. Altuntas, J. M. Johnson, and V. K. Tuohy
Autoimmune Targeted Disruption of the Pituitary-Ovarian Axis Causes Premature Ovarian Failure
J. Immunol., August 1, 2006; 177(3): 1988 - 1996.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.