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Mol. Hum. Reprod. Advance Access published online on January 18, 2006
Molecular Human Reproduction, doi:10.1093/molehr/gah243
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 13, 2005
Revised October 20, 2005
Accepted October 26, 2005

Article

Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes

C.C.W. Chan 1 *, V.W.S. Liu 1, E.Y.L. Lau 1, W.S.B. Yeung 1, E.H.Y. Ng 1, and P.C. Ho 1

1 Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China

* To whom correspondence should be addressed.
C.C.W. Chan, E-mail: cwcchan{at}graduate.hku.hk


  Abstract

Previous studies analysing the incidences of mitochondrial DNA (mtDNA) deletions and mtDNA content in unfertilized oocytes in relation to donors’ age have been controversial. The objective of the study was to compare these two parameters in unfertilized oocytes and relate them to the donors’ age. Fifty-two women donated 155 unfertilized metaphase II (MII) oocytes. The incidence of 4977 bp deletion was 34.6%, and the mtDNA copy number was 598 350 ± 265 862. Women ≥35 years of age had a significantly higher incidence of 4977 bp deletion, lower mtDNA copy number, higher FSH level and poorer ovarian response when compared with younger women. The mtDNA copy number was negatively correlated with the donor’s age. The higher incidence of mtDNA deletion and lower mtDNA copy number in older women suggested that these two parameters may reflect ovarian ageing.

Keywords: age/deletion/mitochondrial DNA copy number/unfertilized oocyte.
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