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Mol. Hum. Reprod. Advance Access published online on February 2, 2006
Molecular Human Reproduction, doi:10.1093/molehr/gal002
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received November 2, 2005
Accepted December 12, 2005

Article

Polymorphisms in the promoter regions of the matrix metalloproteinases-7, -9 and the risk of endometriosis and adenomyosis in China

Kang Shan 1, Zuo Lian-Fu 2, Du Hui 1, Guo Wei 2, Wang Na 2, Jin Xia 1, and Li Yan 2 *

1 Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, China
2 Department of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, China

* To whom correspondence should be addressed.
Li Yan, E-mail: lykx1962{at}yahoo.com.cn


  Abstract

Matrix metalloproteinases (MMPs) may contribute to the development of endometriosis. The aim of this study was to assess the effects of the polymorphisms in the promoters of MMP-7 (181A/G) and MMP-9 (1562C/T) on the risk of occurrence of endometri-osis and adenomyosis. We genotyped 219 patients (143 women with endometriosis, 76 women with adenomyosis) and 160 control women in North China. There was a significant difference in frequency of the MMP-7 genotype between endometriosis and controls (P = 0.01) and also between adenomyosis and controls (P = 0.01). The frequency of the G allele in two groups of patients (7.3 and 7.9%) was significantly higher than in the controls (2.8%) (P = 0.01 and 0.01, respectively). Compared to the A/A genotype, the genotype with the -181G allele showed a significantly increased susceptibility to both diseases, with adjusted odds ratio of 2.62 [95% confidence interval (CI) = 1.17-5.87] for endometriosis and 3.14 (95% CI = 1.26-7.81) for adenomyosis. However, the overall genotype and allelotype distribution of the MMP-9 in the two case groups were not different from that of controls. We conclude that MMP-7-181A/G polymorphism has a potential to be a susceptibility factor for endometriosis and adenomyosis while MMP-9-1562C/T polymorphism may not provide a useful marker to predict susceptibility to endometriosis and adenomyosis, at least in women from North China.

Keywords: adenomyosis/endometriosis/matrix metalloproteinase-7/matrix metalloproteinase-9/single nucleotide polymorphism.
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[Abstract] [Full Text] [PDF]


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