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Mol. Hum. Reprod. Advance Access published online on February 15, 2006
Molecular Human Reproduction, doi:10.1093/molehr/gal010
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org
Received November 10, 2005
Revised December 29, 2005
Accepted January 9, 2006

Article

Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis

K.J. Hutt 1, E.A. McLaughlin 2 *, and M.K. Holland 3

1 Kansas University Medical Centre, Kansas City, KS, USA
2 ARC Centre of Excellence in Biotechnology & Development, Reproductive Science Group, University of Newcastle, Callaghan, New South Wales, Australia
3 Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia

* To whom correspondence should be addressed.
E.A. McLaughlin, E-mail: eileen.mclaughlin{at}newcastle.edu.au


  Abstract

Paracrine signalling between the oocyte and its surrounding somatic cells is fundamental to the processes of oogenesis and folliculogenesis in mammals. The study of animal models has revealed that the interaction of granulosa cell-derived kit ligand (KL) with oocyte and theca cell-derived c-Kit is important for multiple aspects of oocyte and follicle development, including the establishment of primordial germ cells within the ovary, primordial follicle activation, oocyte survival and growth, granulosa cell proliferation, theca cell recruitment and the maintenance of meiotic arrest. Though little is known about the specific roles of KL and c-Kit during human oogenesis, the expression profiles for KL and c-Kit within the human ovary suggest that they are also functionally relevant to female fertility. This review details our current understanding of the roles of KL and c-Kit within the mammalian ovary, with a particular focus on the functional diversity of this receptor-ligand interaction at different stages of oocyte and follicle development.

Keywords: c-kit/folliculogenesis/kit ligand/ovary/stem cell factor.
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