Skip Navigation



Mol. Hum. Reprod. Advance Access published online on April 5, 2006
Molecular Human Reproduction, doi:10.1093/molehr/gal029
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
12/4/269    most recent
gal029v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Carvalho, C. M.B.
Right arrow Articles by Pena, S. D.J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carvalho, C. M.B.
Right arrow Articles by Pena, S. D.J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 28, 2005
Accepted February 16, 2006

Article

No association found between gr/gr deletions and infertility in Brazilian males

Cláudia M.B. Carvalho 1, Luciana W. Zuccherato 1, Luciana Bastos-Rodrigues 1, Fabrício R. Santos 2, and Sérgio D.J. Pena 1 *

1 Departamento de Bioquímica e Imunologia, Belo Horizonte, Minas Gerais, Brazil
2 Departamento de Biologia Geral Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

* To whom correspondence should be addressed.
Sérgio D.J. Pena, E-mail: spena{at}dcc.ufmg.br


  Abstract

The Y chromosome carries several spermatogenesis genes distributed in three regions: AZFa, AZFb and AZFc. Microdeletions in these regions have been seen in 10% of sterile males with azoospermia or oligozoospermia, the most frequent of them being characterized by a complete deletion of AZFc region. A partial AZFc deletion named gr/gr has been singled out as a risk factor for spermatogenic failure. However, other authors have diagnosed it as a polymorphic deletion with no clinical relevance. We decided to investigate the association of gr/gr deletion and infertility in Brazilian males. We analysed 350 individuals (110 azoospermic, 122 fertile and 118 presumably fertile) and observed 12 g/gr deletions: five in infertile men (4.5%), three among fertile males (2.5%) and four in probably fertile individuals (3.4%). These differences were not statistically significant. Then, we decided to ascertain whether the clinical impact of the gr/gr deletion was associated with the type of Y chromosome. We have identified Y-chromosome haplogroups using 22 unique event polymorphisms (UEPs). Among the individuals with the gr/gr deletion, we found haplogroups R, K*, F*, E1, E3b2 and E3b*, all of which are common in white Brazilian males, and none revealed a particular association with infertility. Taken together, these results show no evidence of association between the occurrence of gr/gr deletion and male infertility.

Keywords: AZFc/gr-gr deletion/male infertility/minisequencing/Y chromosome.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
L. Visser, G.H. Westerveld, C.M. Korver, S.K.M. van Daalen, S.E. Hovingh, S. Rozen, F. van der Veen, and S. Repping
Y chromosome gr/gr deletions are a risk factor for low semen quality
Hum. Reprod., October 1, 2009; 24(10): 2667 - 2673.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Lu, J. Zhang, Y. Li, Y. Xia, F. Zhang, B. Wu, W. Wu, G. Ji, A. Gu, S. Wang, et al.
The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population
Hum. Mol. Genet., March 15, 2009; 18(6): 1122 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
C Krausz, C Giachini, Y Xue, M K O'Bryan, J Gromoll, E R.-d. Meyts, R Oliva, I Aknin-Seifer, E Erdei, N Jorgensen, et al.
Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background
J. Med. Genet., January 1, 2009; 46(1): 21 - 31.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
J. Zhang, P.-q. Li, Q.-h. Yu, H.-y. Chen, J. Li, and Y.-s. He
Development of a multiplex quantitative fluorescent PCR assay for identification of rearrangements in the AZFb and AZFc regions
Mol. Hum. Reprod., June 1, 2008; 14(6): 371 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Stouffs, H. Tournaye, J. Van der Elst, P. Haentjens, I. Liebaers, and W. Lissens
Do we need to search for gr/gr deletions in infertile men in a clinical setting?
Hum. Reprod., May 1, 2008; 23(5): 1193 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M.C. Lardone, D.A. Parodi, R. Valdevenito, M. Ebensperger, A. Piottante, M. Madariaga, R. Smith, R. Pommer, N. Zambrano, and A. Castro
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis
Mol. Hum. Reprod., October 1, 2007; 13(10): 705 - 712.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
A. Ferlin, E. Speltra, A. Garolla, R. Selice, D. Zuccarello, and C. Foresta
Y chromosome haplogroups and susceptibility to testicular cancer
Mol. Hum. Reprod., September 1, 2007; 13(9): 615 - 619.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Giachini, F. Nuti, E. Marinari, G. Forti, and C. Krausz
Partial AZFc deletions in infertile men with cryptorchidism
Hum. Reprod., September 1, 2007; 22(9): 2398 - 2403.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
F. Zhang, C. Lu, Z. Li, P. Xie, Y. Xia, X. Zhu, B. Wu, X. Cai, X. Wang, J. Qian, et al.
Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility
J. Med. Genet., July 1, 2007; 44(7): 437 - 444.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.