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Mol. Hum. Reprod. Advance Access first published online on May 19, 2006
This version published online on May 30, 2006
Molecular Human Reproduction, doi:10.1093/molehr/gal045
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received March 13, 2006
Revised April 1, 2006
Accepted April 4, 2006

Article

Novel function of ovarian growth factors: combined studies by DNA microarray, biochemical and physiological approaches

Ido Ben-Ami 1, Sarit Freimann 2, Leah Armon 2, Ada Dantes 2, Raphael Ron-El 3, and Abraham Amsterdam 4 *

1 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot; Department of Obstetrics and Gynecology, IVF Unit, Assaf Harofeh Medical Centre, Tel-Aviv University, Zerifin, Israel
2 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot
3 Department of Obstetrics and Gynecology, IVF Unit, Assaf Harofeh Medical Centre, Tel-Aviv University, Zerifin, Israel
4 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel

* To whom correspondence should be addressed.
Abraham Amsterdam, E-mail: abraham.amsterdam{at}weizmann.ac.il


  Abstract

Owing to the development of the DNA microarray technique, modulation of gene function can be studied systematically. Considerable attention has been focused on members of the growth factor family to elucidate the main regulators of oocyte maturation and ovarian follicle rupture. Among these growth factors, it was found both in rodents and in humans that amphiregulin (Ar) and epiregulin (Ep) of the epidermal growth factor (EGF) family were dramatically up-regulated by gonadotrophins in the intact ovary and in primary granulosa cells, respectively. Their role in cumulus expansion and oocyte maturation was established in rodents, and their formation under LH stimulation in granulosa cells was demonstrated in humans. To be activated, Ar and Ep must be cleaved by A Disintegrin And Metalloproteinases (ADAMs) family. However, the precise processing of Ar and Ep by the cumulus cells is still obscure. Future investigations using DNA microarray technique may reveal the repertoire of genes activated in Ar- and Ep-stimulated cumulus cells and may help elucidate the molecular basis of ovulation.

Keywords: amphiregulin/EGF-like growth factors/epiregulin/metalloproteinase/oocyte maturation.
This is a new version of this paper as author names have been corrected from the first version
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