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Mol. Hum. Reprod. Advance Access published online on October 27, 2006
Molecular Human Reproduction, doi:10.1093/molehr/gal088
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received September 10, 2006
Accepted September 29, 2006

Article

Association between the apolipoprotein B signal peptide gene insertion/deletion polymorphism and male infertility

B. Peterlin 1 *, B. Zorn 2, M. Volk 1, and T. Kunej 1

1 Division of Medical Genetics, Slovenia
2 Andrology Centre, Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slovenia

* To whom correspondence should be addressed.
B. Peterlin, E-mail: borut.peterlin{at}guest.arnes.si


  Abstract

In male mice heterozygous for a null apolipoprotein B (apoB), allele infertility was noticed. These data led us to investigate a possible role of APOB gene polymorphism and male infertility in humans. In this case-control study, we searched for an association between the insertion/deletion (I/D) polymorphism of the APOB gene and male infertility in 560 Slovene Caucasian men. The study group consisted of 310 infertile patients: 115 with azoospermia and 195 with oligoasthenoteratozoospermia (OAT) and a control group of 250 fertile men. We found a statistically significant difference in the genotype distribution between the two groups ({chi}2 = 6.315, P = 0.043). A separate analysis of azoospermic and OAT patients demonstrated that significant differences in genotype distribution were limited to the OAT group ({chi}2 = 7.011, P = 0.030). The presence of the D allele (DD or ID genotypes) conferred a 1.6 risk [{chi}2 = 6.089, P = 0.014, 95% confidence interval (95% CI) = 1.102-2.347] for male infertility in the OAT group of patients. We did not find a correlation between the I/D polymorphism genotypes and the clinical characteristics of infertile men: sperm concentration (P = 0.102), rapid progressive motility (P = 0.449), normal morphology (P = 0.085) and Johnsen score (P = 0.531). These data suggest that genetic variation in the signal peptide of the APOB gene (I/D polymorphism) might be a risk factor for the development of male infertility.

Keywords: apolipoprotein B/azoospermia/male infertility/oligoasthenoteratozoospermia.
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A. Khattri, R. K. Pandey, N. J. Gupta, B. Chakravarty, M. Deenadayal, L. Singh, and K. Thangaraj
APOB Gene Signal Peptide Deletion Polymorphism Is Not Associated With Infertility in Indian Men
J Androl, November 1, 2009; 30(6): 734 - 738.
[Abstract] [Full Text] [PDF]


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