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Mol. Hum. Reprod. Advance Access published online on October 22, 2007
Molecular Human Reproduction, doi:10.1093/molehr/gam074
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

REGULATION OF SURFACTANT PROTEIN D IN THE MOUSE FEMALE REPRODUCTIVE TRACT IN VIVO

Rebecca E. Oberley#,, Kelli L. Goss*, Darren S. Hoffmann, Kevin A. Ault{dagger}, Traci L. Neff+, Kyle H. Ramsey{ddagger} and Jeanne M. Snyder*

# Department of Medicine, National Jewish Medical and Research Center, Denver, CO, 80206 USA * Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA + Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA {dagger} Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30303, USA {ddagger} Department of Microbiology and Immunology, Chicago College of Osteopathic, Medicine Midwestern University, Downers Grove, Illinois 60515, USA

Address correspondence: Rebecca E. Oberley, Ph.D. Department of Medicine National Jewish Medical and Research Center Denver, CO, 80206 USA FAX: 303-270-2249 Telephone: 303-398-1749 E-mail: oberleyr{at}njc.org

Surfactant protein D (SP-D) plays a role in innate immunity in the lung and is expressed at many other mucosal surfaces throughout the human body. In this study, we show that SP-D mRNA and protein are present in the murine female reproductive tract; i.e., in the vagina, cervix, uterus and oviduct. SP-D protein is primarily localized to epithelial cells lining the genital tract and is also present in secretory material within the lumen of the uterus and cervix. The levels of SP-D mRNA in the uterus vary by a factor of 10 during the estrous cycle with peak levels present at estrus and the lowest levels at diestrus. In contrast, SP-D mRNA levels in the lung do not change during the estrous cycle. Since SP-D is an innate host defense protein that is present in the mouse reproductive tract, we studied the influence of infection on SP-D levels in vivo. We found that Chlamydia muridarum infection caused an increase in the SP-D protein content of reproductive tract epithelial cells. These data are suggestive that SP-D may play a role in innate immunity in the female reproductive tract in vivo.

Key Words: Female reproductive tract/infection/mouse/regulation/SP-D

Submitted on September 13, 2007; accepted on September 21, 2007.


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