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Mol. Hum. Reprod. Advance Access published online on November 29, 2007
Molecular Human Reproduction, doi:10.1093/molehr/gam083
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Gene Expression Profile in Labouring and Non-Labouring Human Placenta Near Term

V. Sitras1,4,*, R.H. Paulssen2,*, H. Grønaas3, Å. Vårtun1 and G. Acharya1

1Department of Obstetrics and Gynaecology, University Hospital of North Norway and Institute of Clinical Medicine, University of Tromsø, Post Box 24, N- 9038 Norway 2Laboratory of Molecular Medical Research, Institute of Clinical Medicine, University of Tromsø, LabForum, Department of Medical Genetics, University of Tromsø, N-9037, Tromsø, Norway 3Department of Medical Genetics, University Hospital of North Norway, N-9037 Tromsø, Norway

4 Corresponding author: V. Sitras, MD Department of Obstetrics and Gynaecology, University Hospital of North Norway, Post Box 24, N- 9038, Tromsø, Norway. Tel.: +47 776 26 000; Fax: +47 776 26 421; E-mail address: Vasilis.Sitras{at}unn.no

The duration of pregnancy and initiation of labour is thought to be controlled by fetal, maternal and placental factors. The aim of this study was to investigate whether labour influences gene expression in placenta near term. Placental samples were obtained from 27 women after vaginal delivery (labouring) and 17 samples from women after elective Caesarean section (non-labouring). All women were Caucasian and had uncomplicated pregnancies. For global gene expression analysis, 17 human oligo-arrays were used, representing 24650 genes each. An empirical Bayes analysis was applied in order to find differentially expressed genes. About 8000 genes that were represented on the arrays met our quality criteria. In labouring placentas, 92 genes were down-regulated and 94 genes were up-regulated, compared to non-labouring placentas. However, none of these were differentially expressed at a significant level (>2.5-fold change and a p-value of < 0.01). We conclude that gene expression in near term human placenta is not significantly altered by labour.

Key Words: Gene expression/Parturition/Placenta

* These authors contributed equally to this work.

(Current address: Åsryggen 14, 1166, Oslo)

Submitted on September 14, 2007; resubmitted on November 8, 2007; accepted on November 27, 2007.


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